Sodium tetrachloroaurate(III) dihydrate as catalyst enables a simple and mild removal of tert-butyl(dimethyl)silyl (TBS) protecting groups. A selective deprotection of aliphatic TBS ethers is possible in the presence of aromatic TBS ethers, aliphatic triisopropylsilyl ethers, aliphatic tert -butyl(diphenyl)silyl ethers, or sterically hindered ...

Anyone has suggestion(s) on how to easily and efficiently remove excess silyl protected alcohols from a reaction mixture.

2016年7月1日 · To me, aqueous workup help a lot to remove TBAF if your product is not too soluble or unstable in water. Also, TBAF is mostly used as the floride anion source because its solubility in organic solvent.

2022年5月9日 · After one min of stirring, tetrabutylammonium fluoride solution (19 mL, 1.0 M in THF, 19 mmol, 1.2 equiv) (Note 4) is added via syringe dropwise over five min (Figure 1A). The reaction mixture is then allowed to stir (300 rpm) at 23 °C for 30 min (Note 5). Then, the rubber septum is removed, and calcium carbonate (8.2 g,

当分子内没有对强酸敏感的官能基存在时，可用 HCl-MeOH, HCl-Dioxane 体系去除TBS，若有对强酸敏感的官能基存在时，则可选用AcOH-THF体系去除。 usawang 位阻大时， TBAF脱不掉TBS，用HF.pyridine试一试，成功地可能性非常大，祝你好运。

现在脱化合物上的tbs（酚羟基保护）和糖上的tms保护，用tbaf很快就有掉了，有个相对主要的点产生，问题是，当所有保护基脱除以后，产品极性变得非常大！

2007年1月18日 · The procedure includes addition of a sulfonic acid resin and calcium carbonate, followed by filtration and evaporation. This method eliminates the tedious aqueous-phase extraction process to remove excess TBAF and materials derived from TBAF, thereby making the protocol highly amenable to multiple TBS deprotections.

求助各位大神，我用TBSCl保护了一个羟基，化合物的另一端有Boc。想问下各位大神，如何脱去TBS，而又不影响到Boc。万分感谢

The TBS protecting group protects alcohols in organic synthesis, and is deprotected with fluoride anions (e.g., TBAF) or strong acids. This bulky silyl PG is resilient, allowing for selective/ orthogonal deprotection of similar groups like TMS.

2010年9月9日 · An effective, catalytic method has been developed to remove TBS and THP groups from protected alcohols. TBS and THP ethers were selectively cleaved using a catalytic amount of NO + BF 4 − (5 mol%) in methanol at room temperature.