2020年11月2日 · In this study, we determined how modifying the dose and route of SNP-7/8a immunization influenced CD8 + T cell responses. Mice were vaccinated with SNP-7/8a …

2023年8月3日 · Reps1 and Adpgk neoantigen peptides are widely reported and used in MC38 syngenic model. However, they were not included because both were undetected by …

2019年2月14日 · M1 vaccine induces neoantigen specific immune responses against MC38 cells. Mice were vaccinated with three biweekly injections of M1 vaccine, which encodes 10 …

These data demonstrate that protection from MC38 in the prophylactic setting is dependent on the magnitude of pre-existing Reps1-specific CD8 T cell responses, which is best induced by …

2020年11月12日 · Using the MC38 model with forced expression of KRAS-G12D, we combined the 27-mers encoding Adpgk and Copg1 neoantigens with the KRAS-G12D 23-mer in …

2020年1月13日 · Here, we show that Reps1 LP is particulate in aqueous solution and induces high magnitude CD8 T-cell responses when admixed with a variety of adjuvants (that is, PP …

We next evaluated the capacity of nanoSTING-vax to enhance CD8 + T cell responses to two established tumor neoantigenic peptides arising from mutations in the proteins Reps1 …

2023年11月15日 · 近日， 天津医科大学医学技术学院&基础医学院尹海芳教授团队 在国际权威期刊 Molecular Therapy 在线发表了题为“Complete remission of tumors in mice with …

2018年7月23日 · To test whether LADD can elicit neoantigen-specific CD8 + T cells, we constructed an LADD strain expressing MC38 neoepitopes Adpgk and Reps1 (LADD-Neo) …

Reps1 and Adpgk neoantigen peptides are widely reported and used in MC38 syngenic model. However, they were not included because both were undetected by sequencing. Cell line …