2023年1月1日 · Rete ridges (RRs) are distinct undulating microstructures at the junction of the dermis and epidermis in the skin of humans and certain animals. This structure is essential for enhancing the mechanical characteristics of skin and preserving homeostasis.

The epidermis forms an undulating appearance, with intermittent regular protrusions of the epidermis layer (rete ridges or pegs) into the upper layers of the underlying dermis. In some areas of the body such as the palms and soles, the rete pegs are less pronounced.

Rete ridges (rete pegs) are extensions of the epidermis, projecting into the underlying connective tissue (dermis) (Figure 1 and Figure 2). They have two essential roles: (1) acting as microniches for epidermal SCs [ 41 , 42 ] and (2) to avoid scar formation; scar tissue lacks rete ridges, which leads to malfunctions such as shearing off more ...

2024年11月1日 · Between the epidermis layer at the top and the dermis layer below, the basal keratinocytes form an interface with sinusoidal-like geometry termed rete ridges. In previous computational work we showed that the rete ridges contribute to lower delamination risk by increasing surface area and reducing the stress jump across the interface.

Rete ridges surround the dermal papillae, which can be seen as small extensions protruding from the papillary dermis within the epidermis. These two structures are perfectly embedded; the alternation of a rete ridge with a dermal papilla creates a …

We utilized a massively parallel, multi-species single-cell transcriptomics approach to identify the cellular signaling interactions that support rete ridge formation in humans and pigs but not mice. Validation of these mechanisms included in-vivo immunostaining, wound healing assays, and knockout pig models.

2022年11月14日 · The dermis is divided into 2 layers: the papillary dermis and the reticular dermis. The papillary dermis is the superficial layer, lying deep into the epidermis. The papillary dermis is composed of loose connective tissue that is highly vascular.

2023年1月1日 · Rete ridges (RRs) are distinct undulating microstructures at the junction of the dermis and epidermis in the skin of humans and certain animals. This structure is essential for enhancing the mechanical characteristics of skin and preserving homeostasis.

2023年10月1日 · The undulating microstructure rete ridge (RR) located at the junction between the dermis and epidermis plays a crucial role in improving skin mechanical properties and maintaining skin homeostasis. However, the investigation of RR microstructures is usually neglected in current tissue engineering fo …

Between the epidermis layer at the top and the dermis layer below, the basal keratinocytes form an interface with sinusoidal-like geometry termed rete ridges. In previous computational work we showed that the rete ridges contribute to lower delamination risk by increasing surface area and reducing the stress jump across the interface.