ARV-471是一种由 Arvinas 和 辉瑞（Pfizer） 合作开发的口服 PROTAC 雌激素受体降解剂，用于治疗 雌激素受体阳性（ER+）/ 人表皮生长因子受体 2 阴性（HER2-） 的局部晚期或转移性乳腺癌患者。

The Advanced Reconnaissance Vehicle (ARV) is an armored vehicle program initiated by the United States Marine Corps (USMC) to replace the aging LAV-25 family of vehicles, which has been in service since the 1983.

Take special care with REYDIN: Tell your doctor: If you develop a rash, or show any general signs of allergy (rash, accompanied by fever, general feeling of being ill, tiredness, muscle or joint aches, sores, oral scrapes, eye infection, facial swelling, a serious liver infection or swelling of the skin. If you develop changes in body fat have been seen in …

This annex contains information on ARV drugs for which there are paediatric indications, formulations or sufficient information and evidence to provide guidance on prescribing and dosing for infants, children and adolescents.

ARV-110 和 ARV-766 都是AR降解剂， ARV-110不能降解AR L702H突变，而ARV-766是泛AR降解剂，可以降解AR L702H突变，进一步增加患者人群范围。 ARV-766与ARV-110相比，在结构上主要有3处不同，包括将 中间的六元环改成取代的四元环，将左侧芳香环上氯原子替换成甲氧基以及将氟取代的沙利度胺替换为氟取代的苯甲酰胺，苯甲酰胺这一类CRBN配体有选择性高和血浆稳定性高等优点。 今年的 ESMO 会议上，ARV-766展示了非常好的临床1/2期活性，基于 …

2024年9月12日 · These guidelines include recommendations on baseline laboratory evaluations, treatment goals, benefits of ART and considerations when initiating therapy, choice of the initial regimen for ART-naive people with HIV, ARV drugs or combinations to avoid, management of treatment failure, optimizing ARV regimens, management of adverse effects and ...

TAF 25 mg and TAF + FTC + DTG (TAF 25 mg, emtricitabine 200 mg, dolutegravir 50 mg, fixed-dose combination) can be used once daily for adolescents living with HIV weighing at least 25 kg. The TAF dose is reduced to 10 mg when administered in the context of boosted regimens.

ARV-471是一款新型口服雌激素受体（ER）靶向性蛋白水解靶向嵌合体（PROTAC）蛋白降解剂，由辉瑞与Arvinas联合开发，用于治疗 雌激素受体阳性/人表皮生长因子受体2阴性（ER+/HER2-）乳腺癌 患者。 ARV-471是一种口服生物可利用的PROTAC®蛋白降解剂，专门靶向和降解雌激素受体（ER）。 ER是大多数乳腺癌中众所周知的疾病驱动因素。 在临床前研究中， ARV-471在肿瘤细胞中表现出近乎完全的ER降解，作为单药疗法在多种ER驱动的异种移植模型中有效诱 …

Use of ARV drugs for HIV prevention refers to the HIV prevention benefits of ARV drugs and includes ARV drugs for preventing the mother-to-child transmission (PMTCT) of HIV, ARV drugs to reduce the transmission of HIV to serodiscordant sexual partners and ARV drugs to prevent the acquisition of HIV when a person is exposed (post-exposure ...

2022年11月24日 · 11月23日，PROTAC明星企业 Arvinas 在SABCS前几周就提前公布了旗下核心管线ARV-471治疗重度经治的HR+/HER2-乳腺癌的临床二期扩展试验（NCT04072952、代号VERITAC）初步结果。