rgma是一种糖基磷脂酰肌醇锚定糖蛋白，在中枢神经系统中作为关键的轴突引导蛋白。 其结构特性使其能够与受体NEO1/neogenin结合，进而发挥多重功能。 RGMA不仅调节神经管闭合、抑制神经突生长和皮层神经元分支，还参与调节炎症反应，并在中枢神经系统疾病中 ...

Repulsive guidance molecule A (RGMa) is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. Together with BMPR1A and BMPR1B, as well as ACVR2A and BMPR2, it binds BMPs thereby activating the intracellular SMAD1/5/8 signalling pathway. [5] In humans this protein is encoded by the RGMA gene. [6]

2020年9月29日 · rgma是轴突生长的抑制剂，是中枢神经系统（cns）损伤后抑制神经元再生和功能恢复的重要因素。 elezanumab正被研究治疗脊髓损伤、多发性硬化症和 ...

该基因编码排斥性引导分子家族的成员。 编码的蛋白质是糖基磷脂酰肌醇锚定糖蛋白，在发育中和成人中枢神经系统中起轴突导向蛋白的作用。 这种蛋白质也可能在某些癌症中起到肿瘤抑制因子的作用。 交替剪接导致多个转录本变体。 [RefSeq 提供，2009 年 10 月] This gene encodes a member of the repulsive guidance molecule family.

2023年11月22日 · Here, we demonstrated that RGMa concentration was elevated in the cerebrospinal fluid of both patients with ALS and transgenic mice overexpressing the mutant human superoxide dismutase1 (mSOD1 mice). Treatment with humanized anti-RGMa monoclonal antibody ameliorated the clinical symptoms in mSOD1 mice.

2024年12月25日 · RGMA (Repulsive Guidance Molecule BMP Co-Receptor A) is a Protein Coding gene. Diseases associated with RGMA include Autism Spectrum Disorder and Intracranial Hypertension. Among its related pathways are Nervous system development and Netrin-1 signaling. Gene Ontology (GO) annotations related to this gene include coreceptor activity.

Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin). RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury .

2012年3月1日 · RGMa (repulsive guidance molecule a) was the first identified molecule that possessed the necessary functional activity to repulse and steer growth cones to their target in the brain. By binding to its neogenin receptor, RGMa caused the collapse of growth cones and encouraged axons to grow along specific trajectories in vitro.

人源化抗 RGMa 单克隆抗体治疗改善了 mSOD1 小鼠的临床症状。 组织化学分析表明，抗 RGMa 抗体通过抑制肌动蛋白解聚，显着减少 mSOD1 小鼠运动神经元中突变型 SOD1 蛋白的积累。

2015年3月24日 · In vitro, RGMa monoclonal antibodies (mAbs) reversed RGMa-mediated neurite outgrowth inhibition and chemorepulsion. In animal models of CNS damage and MS, RGMa antibody stimulated regeneration and remyelination of damaged nerve fibers, accelerated functional recovery, and protected the retinal nerve fiber layer as measured by clinically ...