Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. [5] BMP-2 like other bone morphogenetic proteins, [6] plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine -cytokine receptor interaction.

2013年11月15日 · 国外研究表明，rhBMP-2基因已在部分工程细胞株中获得了高效表达，如真核细胞的非洲绿猴肾（COS）和中国仓鼠卵巢细胞（CHO）等，但其rhBMP-2在真核细胞中的表达量实在太低，产量远不能满足临床应用的需求。

Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a commonly used growth factor in bone regeneration due to its high potency and ability to induce osteogenic differentiation of osteoblasts and osteoblast precursors. When designing delivery systems for rhBMP-2, the activity of the loaded and released protein is an important consideration.

Because of its diverse functions and osteogenic potential, the Food and Drug Administration (FDA) approved usage of recombinant human BMP-2 (rhBMP-2) during spinal fusion surgery, tibial shaft repair, and maxillary sinus reconstructive surgery.

In recent years, recombinant human bone morphogenetic protein-2 (rhBMP-2) has been introduced as a therapeutic option in the treatment of several congenital and acquired craniofacial defects. Although there have been promising clinical results, the ...

2023年9月29日 · In vivo, rhBMP-2 functionalized mimetic periosteum demonstrated regenerative potential in the treatment of rat critical-size femoral defects with highly efficient healing and functional recovery...

2024年4月29日 · Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow mesenchymal stromal cells (hBM-MSCs) have been thoroughly studied for research and translational bone regeneration purposes. rhBMP-2 induces bone formation in vivo, and hBM-MSCs are its target, bone-forming cells.

2023年8月24日 · This review presents the status of rhBMP-2 use in maxillofacial surgery, focusing on its clinical application, efficacy, safety, and limitations. Studies have demonstrated rhBMP-2’s potential to reduce donor site morbidity and increase bone height in sinus and ridge augmentation; however, it may not outperform autogenous bone grafts.

2019年8月19日 · Recombinant human bone morphogenetic protein-2 (rhBMP-2) is one of the most commonly used osteogenic agents in the craniofacial skeleton. This study reviews the safety and efficacy of rhBMP-2 as applied to craniofacial reconstruction and assesses the level of scientific evidence currently available.

2011年11月15日 · 重组人骨形态发生蛋白（rhBMP）-2就此诞生。 2011年6月28日，北美脊柱学会（NASS）官方杂志《脊柱杂志》（SpineJ）最新一期全部刊登rhBMP-2相关综述、述评、临床研究等文章，就rhBMP-2在 ...