RHEB - Wikipedia
RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the …
Rheb泛素化调控生长因子诱导的mTORC1激活 - 知乎
研究结论：Rheb泛素化需要TSC复合物的GAP活性，其中TSC2可能主要促进Rheb的单泛素化。另外，Rheb的泛素化与其失活密切相关，而EGF处理会抑制Rheb的泛素化。 2.RNF152是Rheb …
mTOR 通路 | Cell Signaling Technology
小分子 GTP 酶 Rheb，在与 GTP 结合的状态下，是 mTORC1 激酶活性所需的强效刺激剂，并且受到其 GAP（即结节性硬化异二聚体 TSC1/2）的负性调控。绝大多数上游输入信号通过 Akt …
RHEB Gene - GeneCards | RHEB Protein | RHEB Antibody
2024年12月25日 · RHEB (Ras Homolog, MTORC1 Binding) is a Protein Coding gene. Diseases associated with RHEB include Focal Cortical Dysplasia, Type Ii and Isolated Focal Cortical …
Mechanisms of mTORC1 activation by RHEB and inhibition by …
2017年12月13日 · Here we present the 3.0 ångström cryo-electron microscopy structure of mTORC1 and the 3.4 ångström structure of activated RHEB–mTORC1. RHEB binds to mTOR …
Rheb参与调节线粒体能量产生 - 知乎 - 知乎专栏
Rheb是一种小H-Ras-like GTPase，是溶酶体表面 雷帕霉素 复合物1（mTORC1）机制靶点的直接和必要激活剂。在研究Rheb在突触信号传导和细胞分化中的作用是，发现Rheb与丙酮酸代谢 …
RHEB 蛋白, Human (GST) | MCE - MCE-生物活性分子大师
RHEB is an important small GTPase that acts as an allosteric activator of the mTORC1 complex, a key nutrient sensor that controls cell growth and biomass production. In response to signals …
A small molecule inhibitor of Rheb selectively targets mTORC1 ... - Nature
2018年2月7日 · Here, we report the discovery of a small molecule (NR1) that binds Rheb in the switch II domain and selectively blocks mTORC1 signaling. NR1 potently inhibits mTORC1 …
Nature | mTORC1通路的特异底物激活机制 - 知乎 - 知乎专栏
研究细致地解析了细胞氨基酸水平变化可特异地调控mTORC1对转录因子TEFB磷酸化，揭示了Birt–Hogg–Dubé syndrome背后的致病机制。 mTORC1分别通过TSC-Rheb和Rag GTPase响 …
RHEB Ras homolog, mTORC1 binding [ (human)] - National …
RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia. Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase …