2005年8月15日 · RhoGDI (Rho GDP-dissociation inhibitor) was identified as a down-regulator of Rho family GTPases typified by its ability to prevent nucleotide exchange and membrane …

2024年2月19日 · Rho GTPases是一类重要的细胞信号传导蛋白，在细胞内起着关键的调控作用。 它们是小的 GTP酶 ，属于 Ras超家族 ，包括RhoA、RhoB、RhoC、Rac1、Rac2、Cdc42等 …

RHO protein GDP dissociation inhibitor of Rho proteins (rho GDI) regulates GDP/GTP exchange. The protein plays an important role in the activation of the oxygen superoxide-generating …

2005年7月1日 · Based largely on biochemical and in vitro evidence, GDP dissociation inhibitor (GDI) is proposed to regulate both the interactions of Rho GTPases with regulators and …

GDI mediates the release of RHO GTPases from the membrane, maintains them in an inactivated state, and safeguards them against degradation or nonspecific activation by RHOGEFs …

2011年7月22日 · RHO-specific guanine nucleotide dissociation inhibitors (RHOGDIs) are a family of proteins that have key roles in the regulation of the RHO GTPases. RHOGDIs function...

Rho-specific guanine nucleotide dissociation inhibitors (RhoGDIs) play a crucial role in the regulation of Rho family GTPases. They act as negative regulators that prevent the activation …

The GDI proteins are key components of the regulatory machinery controlling both the timing and the localization of Rho GTPase activity. Recent structural work has provided significant insight …

2000年2月4日 · The GDI acts as an important inhibitor of signaling through Rho family GTP-binding proteins, and the X-ray crystallographic structure of the Cdc42/GDI complex reported …

RhoGDI (Rho GDP-dissociation inhibitor) was identified as a down-regulator of Rho family GTPases typified by its ability to prevent nucleotide exchange and membrane association. …