2020年3月23日 · RhoGAPs are more promiscuous than RhoGEFs to confine Rho activity gradients. Our resource enabled us to uncover a multi-RhoGEF complex downstream of G …

In turn, Rho GTPases are regulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). To understand how endothelial cells initiate changes in …

RHOGAP interacts with the switch I and II regions [3,133] and the P-loop of the RHO protein. The GAP domain accelerates the intrinsic GTP hydrolysis by RHO proteins in two ways. First, it …

Rho GTPase-activating proteins (RhoGAPs) can terminate Rho GTPases by stimulating their intrinsic rate of GTP hydrolysis. This rapidly converts Rhos to their GDP-bound state, and …

2016年6月15日 · Rho GTPases, which cycle between a GTP-bound active form and a GDP-bound inactive form, regulate cytoskeletal and cell adhesion dynamics and thus are crucial for …

2024年1月3日 · Rho GTPases have what seems to be an excessively large repertoire of regulators: at least 80 different GEFs and 70 different GAPs 92 regulating the 3 most …

To date, more than 70 RhoGAPs have been identified in eukaryotes, ranging from yeast to human, and based on sequence homology of their RhoGAP domain, we have grouped them …

Three classes of regulatory proteins are involved in balancing Rho GTPases between the on and off states: the guanine nucleotide exchange factors (GEFs), which promote the release of …

Rho GTP 酶是细胞骨架的中央调节因子，在人类中由 145 个多域鸟嘌呤核苷酸交换因子 (RhoGEF) 和 GTP 酶激活蛋白 (RhoGAP) 控制。 Rho 信号传导模式如何在动态细胞空间中建 …

2023年2月21日 · We show that a prometastatic RhoGAP, ARHGAP8/BPGAP1, binds to inactive Rac1 and localizes to lamellipodia. BPGAP1 recruits the RacGEF Vav1 under epidermal …