RhoG (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein , and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G proteins [ 5 ] and is encoded by the gene RHOG .

2024年12月25日 · RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include Familial Hemophagocytic Lymphohistiocytosis 5 and Lymphoproliferative Syndrome, X-Linked, 2. Among its related pathways are Constitutive Signaling by Aberrant PI3K in Cancer and Signaling by Rho GTPases.

RhoG 是小 GTP 酶 Rho 家族的多面成员，与 Rac 亚家族成员具有最高的序列同一性。 它充当分子开关，激活后在调节免疫细胞的基本过程中发挥核心作用，例如肌动蛋白细胞骨架动力学、跨内皮迁移、存活和增殖，包括炎症期间的免疫功能（例如吞噬作用和吞噬作用 ...

2023年6月28日 · Phagocytosis and trogocytosis are an orchestrated signaling pathway regulated by RhoGTPases like RhoG. RhoG is required for Fcγ Receptor (FcγR) and Complement Receptor 3 (CR3)-mediated phagocytosis. RhoG enables TC21 to regulate TCR-mediated endocytosis, which is critical for T-cell and APC activation modules.

rhog是位于11号染色体的基因。 本词条缺少概述图，补充相关内容使词条更完整，还能快速升级，赶紧来 编辑 吧！

ras 同系物家族成员 G： 该基因编码小 GTP 酶 Rho 家族的一个成员，它在非活性 GDP 结合状态和活性 GTP 结合状态之间循环，并在信号转导级联中充当分子开关。 Rho 蛋白促进肌动蛋白细胞骨架的重组并调节细胞形状、附着和运动。编码的蛋白质促进功能性鸟嘌呤核苷酸交换因子 (GEF) 复合物从细胞质易位 ...

RhoG 是小 GTP 酶 Rho 家族的成员，与 Rac1 和 Cdc42 具有高度序列同一性。 先前的研究表明，RhoG 通过激活 Rac1 和 Cdc42 来介导其作用。 为了进一步了解 RhoG 信号传导机制，我们研究了其潜在的激活途径、下游信号传导特性以及与 Rac1 和 Cdc42 的功能关系。

2019年3月26日 · Here we show that RhoG regulates the number, size, lifetime and maturation stage of FA, as well as SF contractility, suggesting that the role of RhoG in cell migration may be mediated through...

2023年6月28日 · This review focuses on the cellular functions of RhoG, interconnecting different signaling pathways, and speculates the importance of this small GTPase as a prospective target against several pathological conditions.

We propose that biallelic RHOG mutations abrogating its expression specifically impair exocytosis in cytotoxic lymphocytes and ultimately result in FHL. Based on the current FHL classification, 25 RHOG mutations may