RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family ...

2020年3月23日 · Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins...

2021年9月21日 · The RhoGEF Trio contains two GEF domains that differentially activate the small GTPases such as Rac1/RhoG and RhoA. These small RhoGTPases are mainly involved in the remodeling of the actin cytoskeleton. In the endothelium, they regulate junctional stabilization and play a crucial role in angiogenesis and endothelial barrier integrity.

Many cellular processes are controlled by small GTPases, which can be activated by guanine nucleotide exchange factors (GEFs). The RhoGEF Trio contains two GEF domains that differentially activate the small GTPases such as Rac1/RhoG and RhoA. These small RhoGTPases are mainly involved in the remodeling of the actin cytoskeleton.

2022年11月24日 · RhoGEFs (guanine nucleotide exchange factors for small GTPases of the Rho family) are known to be key players in the regulation of cell shape, cell differentiation and cell growth 3, through their...

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs).

RGS proteins for G 12/13 proteins are RhoGEFs, four of which are known to be regulated by G 12 -type proteins: p115-RhoGEF, PSD-95/Disc-large/ZO-1 homology (PDZ)-RhoGEF, leukemia-associated RhoGEF (LARG) and lymphoid blast crisis (Lbc)-RhoGEF.

2013年9月16日 · One prevalent mechanism involves aberrant Rho activation via the deregulated expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs). RhoGEFs promote formation of the...

2016年4月26日 · RhoGTPase在调节细胞骨架形成、基因转录、nucleotideexchangefactor，GEF），能够催化GDP转. 细胞周期及膜泡运输中起着重要的作用，与肿瘤及化为GTP。 其中，起主要作用的是RhoGTPase鸟. 近些年来， 子开关的角色。 这种作用是通过GTP与二磷酸鸟苷RhoGEF已经成为功能蛋白研究的热点，不同领域. 中发挥重要的作用。 kb的DNA序列，并命名为Dbl。 RhoGTPase家族. 目前，在人类当中至少已经鉴定出80. ，并 …

2023年2月13日 · To decipher the mechanisms of RhoGTPase spatiotemporal regulation during epithelial cell division, we generated a transgenic fluorescently tagged library for the 48 Drosophila Rho guanine exchange factors (RhoGEFs) and GTPase-activating proteins (GAPs), and we systematically characterized their endogenous distributions by time-lapse microscopy.