Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphomas with the Tfh phenotype, derived from Tfh cells, often harbor RHOA G17V mutation. We investigated …

Here we demonstrate that RHOA G17V, a highly prevalent mutation present in 70% of angioimmunoblastic T cell lymphoma cases, drives Tfh lineage specification and AITL …

2018年2月12日 · Expression of Rhoa G17V in CD4 + T cells induces Tfh cell specification; increased proliferation associated with inducible co-stimulator (ICOS) upregulation and …

In our mouse studies, expression of Rhoa G17V in CD4 + T cells significantly increases differentiation toward the Tfh lineage, as showed by increased numbers of CD4 + CXCR5 + …

2022年2月1日 · By using a highly sensitive qPCR assay, we confirmed that RHOA Gly17Val (c.50G>T) mutation is specifically associated with AITL or PTCL-TFH, but is not found in other …

2022年10月11日 · Angioimmunoblastic T-cell lymphoma (AITL) is a malignant hematologic tumor arising from T follicular helper (Tfh) cells. High-throughput genomic sequencing studies have …

RhoA G17V小鼠与Tet2fl/fl;Vav-Cre+小鼠杂交，可敲除造血室的Tet2、保留AITL的组织学和免疫表型、形成T细胞淋巴瘤，并且获得mTOR相关基因富集的转录特征。 移植瘤对mTOR抑制剂依 …

2025年3月4日 · Here, we report that RHOA and CD28 variants work in concert to sustain T-cell activation by promoting p300-dependent histone acetylation and show that in lymphomas …

2018年2月12日 · Here we demonstrate that RHOA G17V, a highly prevalent mutation present in 70% of angioimmunoblastic T cell lymphoma cases, drives Tfh lineage specification and AITL …

The RHOA G17V mutation is highly recurrent in follicular helper T-cell (TFH) lymphoma of the angioimmunoblastic type (AITL) (60-70% of cases) and frequently associated with mutations in …