2024年12月25日 · RIC8A (RIC8 Guanine Nucleotide Exchange Factor A) is a Protein Coding gene. Diseases associated with RIC8A include Chronic Maxillary Sinusitis and Fragile X Syndrome . Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity .

2019年7月12日 · Resistance to inhibitors of cholinesterase 8A (Ric8A) is an essential regulator of G protein α-subunits (Gα), acting as a guanine nucleotide exchange factor and a chaperone. We report two crystal...

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene. [5][6][7] RIC8A has been shown to interact with GNAO1, [8] GNA13, [9][8] GNAQ, [8][10] GNAS complex locus, [10] GNAI2, [8] GNAI1 [8] and GNAI3. [8] ^ "Human PubMed Reference:".

2025年2月8日 · chaperone Ric-8A, synembryn-A, resistance to inhibitors of cholinesterase 8 homolog A. Neomorphic Galphao mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies. circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.

2020年2月26日 · Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Gα) and serves as an essential Gα chaperone....

Resistance to inhibitors of cholinesterase 8A (Ric-8A) is a prominent nonreceptor GEF and a chaperone of G protein α-subunits (Gα). Recent studies shed light on the structure of Ric-8A, providing insights into the mechanisms underlying its interaction with Gα. Ric-8A is composed of a core armadillo-like domain and a flexible C-terminal tail.

2024年3月5日 · Title: The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release. Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha(i/o ...

2016年12月23日 · Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Gα Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the interface between the Gαi1 Ras and helical domains, allowing domain separation and nucleotide release.

2016年12月23日 · Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Gα Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the interface between the Gαi1 Ras and helical domains, allowing domain separation and nucleotide release.

Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates.