2022年9月18日 · Rich focus is the caseating subpial or subependymal foci of tuberculous infection in the cortex of the brain 2. It becomes important when a tuberculous focus discharges its contents into the subarachnoid space or into the ventricular system resulting in …

2024年9月2日 · In TBM, the meninges are seeded by MTB and form subependymal collections called Rich foci. These foci can rupture into the subarachnoid space and cause an intense inflammatory response resulting in meningitis symptoms. The exudates caused by this response can encase cranial nerves and cause nerve palsies.

A Rich focus is a tuberculous granuloma occurring within the cortex or meninges of the brain that ruptures into the subarachnoid space, causing tuberculous meningitis. [1]

In the brain, the TB bacilli initiate the development of tuberculous lesions (known as Rich foci) in the meninges or the subpial or subependymal surface . Rich and McCordock demonstrated through postmortem experiments that the rupture of these lesions releases M. tuberculosis into the subarachnoid space or ventricular system, causing ...

2025年2月13日 · Tuberculous meningitis is caused by Mycobacterium tuberculosis. The infection spreads hematogenously from a distant focal point, usually pulmonary tuberculosis and lodges immediately deep to the pia forming Rich foci. These can rupture into the subarachnoid space, forming an exudate.

TBM occurs when subependymal or subpial tubercles, also known as “rich foci” seed during bacillemia of primary infection or disseminated disease [17,18,22,23]. This rupture of the granuloma into the subarachnoid space leads to an intense inflammatory response, which eventually causes meningitis [18,19,21,23].

For CNS tuberculosis, the disease begins with the development of small tuberculous foci (Rich foci) in the brain, spinal cord, or meninges. The location of these foci and the capacity to control them ultimately determine which form of CNS tuberculosis occurs.

Tuberculous meningitis (TBM) develops most often when a caseating meningeal or sub-cortical focus, the Rich focus, discharges its contents into the subarachnoid space. It is recognized that TBM is frequently accompanied by miliary tuberculosis, but the relationship between the development of the Rich focus and miliary tuberculosis remains ...

Rich foci are caseating brain tuberculous (TB) granulomas surrounding the immigrated TB bacilli. Rich foci are hypothesized as an underlying pathological mechanism of TB meningitis. The hypothesis is based on necropsy studies and has rarely been depicted in vivo. Ruptured foci discharge their contents into the neighboring subarachnoid space.

2017年5月1日 · In the 1930s Rich and McCordock proposed that bacteria travel via the blood and form a tuberculoma (Rich foci). These foci may rupture resulting in diffuse meningitis. Previously our laboratory showed that bone marrow derived dendritic cells (DCs) migrate across the blood-brain barrier (BBB) into the CNS during inflammation in vitro and in vivo .