
Regulated IRE1α-dependent decay (RIDD)-mediated …
2022年5月6日 · Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α-dependent decay (RIDD). Accumulating...
Getting RIDD of RNA: IRE1 in cell fate regulation - PubMed
For instance, RIDD cleaves RNA at an XBP1-like consensus site but with an activity divergent from XBP1 mRNA splicing and can either preserve ER homeostasis or induce cell death. Here we review recent findings on RIDD and propose a model of how IRE1 RNase activity might control cell fate decisions.
IRE1α RIDD activity induced under ER stress drives neuronal death …
2021年6月3日 · Three ER-resident transmembrane proteins orchestrate the UPR: inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), and protein kinase RNA (PKR)-like ER kinase (PERK).
Decoding non-canonical mRNA decay by the endoplasmic …
2021年12月15日 · IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD).
The Structure, Activation and Signaling of IRE1 and Its Role in ...
The inositol-requiring enzyme type 1α (IRE1α) possesses several activities: It induces the regulated IRE1-Dependent Decay (RIDD) of specific mRNAs, the unconventional splicing of x-box binding protein 1 (XBP1) mRNA, as well as it interacts with the TNF Receptor Associated Factor 2 (TRAF2) to initiate the c-Jun N-terminal kinase (JNK ...
IRE1α RIDD activity induced under ER stress drives neuronal death …
IRE1 oligomerization and trans-autophosphorylation activate its RNase domain to catalyze the cleavage of the X-binding protein 1 (Xbp1) mRNA, generating the active transcription factor XBP1s 13, which promotes cell survival.
Getting RIDD of RNA: IRE1 in cell fate regulation - ScienceDirect
2014年5月1日 · Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. Intriguingly, via its endoribonuclease activity, IRE1 produces either adaptive or death signals.
Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD
2014年11月6日 · Using an IRE1 RNase inhibitor, STF-083010, selective inhibition of XBP1 splicing indicates that XBP1 promotes cell survival, whereas RIDD leads to cell death, revealing modulation of IRE1 activities as a drug-development strategy.
Regulated IRE1α-dependent decay (RIDD)-mediated …
Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α-dependent decay (RIDD). Accumulating evidence implicates IRE1α in the regulation of lipid metabolism. However, the roles of XBP1s and RIDD in this process remain ill-defined.
Getting RIDD of RNA: IRE1 in cell fate regulation - Cell Press
2014年3月20日 · Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. Intriguingly, via its endoribonuclease activity, IRE1 produces either adaptive or death signals.