Regulated IRE1α-dependent decay (RIDD)-mediated …
2022年5月6日 · Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α …
Getting RIDD of RNA: IRE1 in cell fate regulation - PubMed
For instance, RIDD cleaves RNA at an XBP1-like consensus site but with an activity divergent from XBP1 mRNA splicing and can either preserve ER homeostasis or induce cell death. Here …
IRE1α RIDD activity induced under ER stress drives neuronal death …
2021年6月3日 · Three ER-resident transmembrane proteins orchestrate the UPR: inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), and protein kinase RNA …
Decoding non-canonical mRNA decay by the endoplasmic …
2021年12月15日 · IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD).
The Structure, Activation and Signaling of IRE1 and Its Role in ...
The inositol-requiring enzyme type 1α (IRE1α) possesses several activities: It induces the regulated IRE1-Dependent Decay (RIDD) of specific mRNAs, the unconventional splicing of x …
IRE1α RIDD activity induced under ER stress drives neuronal death …
IRE1 oligomerization and trans-autophosphorylation activate its RNase domain to catalyze the cleavage of the X-binding protein 1 (Xbp1) mRNA, generating the active transcription factor …
Getting RIDD of RNA: IRE1 in cell fate regulation - ScienceDirect
2014年5月1日 · Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. …
Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD
2014年11月6日 · Using an IRE1 RNase inhibitor, STF-083010, selective inhibition of XBP1 splicing indicates that XBP1 promotes cell survival, whereas RIDD leads to cell death, …
Regulated IRE1α-dependent decay (RIDD)-mediated …
Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α-dependent decay (RIDD). …
Getting RIDD of RNA: IRE1 in cell fate regulation - Cell Press
2014年3月20日 · Inositol-requiring enzyme 1 (IRE1) is the most conserved transducer of the unfolded protein response (UPR), a homeostatic response that preserves proteostasis. …