DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN …
2024年2月21日 · In this study, we identified a critical regulatory function of the DUSP4 phosphatase in innate immune signalling. We found that DUSP4 regulates the activation of …
Cellular RNA interacts with MAVS to promote antiviral signaling
To test whether RNase treatment inhibited IRF3 phosphorylation in the absence of an activating nonself RNA ligand, we performed the MAVS activity assay in 293T IRF3 KO cells that stably …
LUBAC is required for RIG-I sensing of RNA viruses - Nature
2023年11月24日 · RIG-I is an intracellular PRR that binds short double-stranded viral RNAs to trigger MAVS-dependent signalling. The RIG-I/MAVS signalling complex requires the …
TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I ...
Here, we demonstrate that loss of TDP-43 induces cytoplasmic immunostimulatory dsRNA accumulation triggering a RIG-dependent type-I and -III IFN response. RIG-I activation is …
RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid ...
2015年12月1日 · We show that influenza B virus induces IRF3 activation, leading to IFN gene expression after viral RNPs (vRNPs) are released into the cytosol and are recognized by RIG-I …
RNA-binding proteins hnRNPM and ELAVL1 promote type-I …
2024年12月20日 · Here, we identify heterogeneous nuclear ribonucleoprotein M (hnRNPM) as a positive regulator of IRF3 phosphorylation and type-I IFN induction downstream of both cGAS …
RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis …
A critical discovery was made showing dual functions of IRF3 in virus infected cells: it not only induces antiviral genes but also triggers apoptotic cell death by the R LR-induced I RF3 …
RIG-I/MAVS 报告基因细胞_raw-lucia isg-CSDN博客
2024年7月4日 · 源于A549的细胞携带一个额外的NF-κB诱导表达分泌型碱性磷酸酶（SEAP）基因构件，该酶的活 性能 够通过SEAP检测试剂QUANTI-Blue™检测定量。 这些RIG-I/MAVS报告 …
[Establishment of RIG-I knockout 293T cell line and its effect on …
2020年1月25日 · In the present study, to explore whether RIG-I is the major receptor for IBV to active the antiviral innate immune response and its effect on IBV replication, RIG-I gene in …
Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory …
2015年9月1日 · Upon sensing of viral RNA and DNA, IRF3 is phosphorylated and recruits coactivators to induce type I interferons (IFNs) and selected sets of IRF3-regulated IFN …