rig-1 和 mda5 等 rig-i 样受体 (rlr) 能检测双链病毒 rna 和 5'-三磷酸短 dsrna。 MDA5 和 RIG-1 会与共有的 caspase 募集结构域相互作用，从而诱导线粒体抗病毒信号转导蛋白 (MAVS) 发生二聚化。

2020年3月13日 · RIG-I (retinoic acid-inducible gene I) and MDA5 (melanoma differentiation-associated protein 5) are regulated by acetylation, deamidation, phosphorylation, SUMOylation, modification with FAT10...

一般认为，rig-i和mda5识别不同构象的双链rna。 RIG-I主要与RNA5'端具有三磷酸基团并于其3'端配对形成双链而中间为单链的RNA相结合，而MDA5则与长双链RNA相结合（图4b）。

mda5（黑色素瘤分化相关蛋白5）是一种 rig-i类受体 dsrna螺旋酶，由ifih1基因编码。 MDA5是RIG-I类受体（RLR）家族的一部分，该家族还包括RIG-I和LGP2，并作为一种 模式识别受体 能够检测病毒。

2021年1月18日 · RIG-I, which enhances IFN production in response to RNA virus infection, was isolated via expression cloning. 15 The human genome encodes three RLRs, RIG-I, melanoma differentiation-associated...

2006年4月9日 · Here we use mice deficient in MDA5 (MDA5-/-) to show that MDA5 and RIG-I recognize different types of dsRNAs: MDA5 recognizes poly (I:C), and RIG-I detects in vitro transcribed dsRNAs....

MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor capable of detecting viruses.

2021年11月5日 · mda5是细胞内的异体rna监测蛋白，属于rig-i样受体家族（rlrs）的重要成员。 MDA5参与多种RNA病毒引起的免疫反应，是天然免疫的一道重要屏障。 RLRs家族共有RIG-I、MDA5及LGP2三个成员，其中RIG-I和MDA5的N端均拥有串联CARDs结构域，可通过CARD-CARD同型相互作用招募MAVS ...

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and I...

RIG-I and MDA5 are the principal sensors of viral dsRNA in the cytoplasm. The interferon-dependent inflammatory response triggered by RLR ligand binding is one of the first and most important lines of defense against infection. RIG-I and MDA5 recognize distinct and complementary sets of viral dsRNA ligands.