RIG-I (retinoic acid-inducible gene I) is a cytosolic pattern recognition receptor (PRR) that can mediate induction of a type-I interferon (IFN1) response. [5] RIG-I is an essential molecule in …

本文主要关注天然免疫系统的PRR部分。 一般认为，PRR包括四类： Toll-like receptors (TLRs)、retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs)、nucleotide oligomerization …

RLRs（RIG-I样受体）位于细胞质中，其中RIG-I感应较短的双链RNA（dsRNA），而另一家族成员MDA5则感应较长的双链RNA。 这两种受体通过适配蛋白MAVS触发I型干扰素和促炎细胞 …

The retinoic acid-inducible gene I (RIG-I) and the RIG-I-like receptor (RLR) protein family are key cytoplasmic pathogen recognition receptors that are implicated in the recognition of viruses …

2022年6月28日 · 维甲酸诱导基因-I[5] （RIG-I，retinoic acid-inducible gene I）是 脊椎动物 细胞质 中的一种 模式识别受体 （PRR），结构上属于 DExD/H-box （英语：DExD/H box proteins） …

2021年8月4日 · Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens,...

2015年5月1日 · Defining the characteristics of RIG-I ligands and the diverse effects on the innate and adaptive immune response when multiple PRR pathways interact is essential for informing …

2021年9月12日 · RIG-I is our first line of defense against RNA viruses, serving as a pattern recognition receptor that identifies molecular features common among dsRNA and ssRNA viral …

2017年6月8日 · RIG-I is a highly important cytosolic pattern recognition receptor (PRR) involved in sensing RNA virus infection and inducing interferon (IFN) production. This gene was first …

2 天之前 · Introduction Innate immune responses are induced by host pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs), leading to …