2020年3月13日 · The structure of full-length RIG-I without RNA ligand showed that RIG-I is in a signalling-repressed, closed conformation that is mediated by specific contacts of CARD2 with …

2024年12月25日 · RIGI (RNA Sensor RIG-I) is a Protein Coding gene. Diseases associated with RIGI include Singleton-Merten Syndrome 2 and Singleton-Merten Dysplasia.Among its related …

The structure of full-length RIG-I without RNA ligand showed that RIG-I is in a signalling-repressed, closed conformation that is mediated by specific contacts of CARD2 with an …

Structure‐based model of RIG‐I activation. RIG‐I contains a pair of amino‐terminal caspase activation and recruitment domains (the signaling domains or CARDs (grey)), an atypical …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively …

2021年1月18日 · Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that play essential roles in innate antiviral immunity. Among the three RLRs …

It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs. …

RIG-I is a cytosolic pathogen recognition receptor. • RIG-I binds to PAMP RNA. • RIG-I initiates the immune response to RNA virus infection. Introduction. The innate immune response …

Introduction. RIG-I (Retinoic acid-inducible gene I) encoded by the DDX58 gene in the human genome (1, 2) and MDA5 (Melanoma Differentiation-Associated protein 5) encoded by the …

2024年4月9日 · RIG-I, MDA5, and LGP2 contain a central helicase and a C-terminal domain (CTD). The tandem caspase activation and recruitment domain (CARD) is located at the N …