2017年9月25日 · The main functions of RING-E3s are to provide the scaffold that allows simultaneous binding of E2 and the substrate protein, and in addition to induce a “closed” E2 ∼ Ub conformation that is primed for attack by the substrate nucleophile [13].

2022年8月30日 · The RING (really interesting new gene) finger (RNF) protein, containing the RING domain, exerts E3 ubiquitin ligase that mediates the covalent attachment of ubiquitin (Ub) to target proteins.

The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes.

2016年10月21日 · 酶E3是目标蛋白识别中的关键角色，通过识别蛋白质N端不稳定的氨基酸信号，选择性地 把目标蛋白降解，从而参与细胞内的多种生理过程。

2021年1月13日 · 膜相关RING-CH (membrane-associated RING-CH，MARCH) 家族是一类属于E3泛素连接酶的环指结构域家族，迄今已发现的MARCH家族成员有11种，分别是 MARCH1～11。 MARCH家族的蛋白分布广泛，能够参与多种细胞功能，如免疫调节。 最新研究表明MARCHs调控抗病毒天然免疫信号通路，如TLR、RLR、cGAS-STING信号通路，从而调节抗病毒天然免疫应答。 文章链接 (免费下载)： https://authors.elsevier.com/a/1cP5gWFfgi%7ELH.

2017年9月25日 · E3 ligases are critical checkpoints for protein ubiquitination, a signal that often results in protein sorting and degradation but has also been linked to regulation of transcription and DNA repair. In line with their key role in cellular trafficking and cell-cycle control, malfunction of …

Membrane-associated RING-CH (MARCH) proteins are RING E3s with a RING-CH domain that differs modestly from the classic RING domain (now termed RING-HC) in the identity of the fourth and fifth coordinating residues and the length of the …

2021年11月16日 · The membrane-associated RING-CH-type finger (MARCH) proteins, which are E3 ubiquitin ligases, have emerged as critical regulators of immune responses by targeting various immune receptors,...

E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of most E3s is specified by a RING domain, which binds to an E2 approximately ubiquitin thioester and activates disc …

The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes.