“Signet-ring” is a term used to describe the histologic appearance of a cell that presents as a large cytoplasmic vacuole, which compresses the nucleus in the form of a crescent, and the content of the vacuoles is variable (e.g., mucin, lipid, or glycogen). [1]

2024年9月2日 · Our study provides a detailed characterization of benign histiocytic signet ring cells in effusion cytology. The differential diagnosis of histiocytic signet ring cells is broad. The most important differential diagnoses are metastatic adenocarcinoma and epithelioid signet ring cell mesothelioma.

In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas. Signet ring cells are most frequently associated with stomach cancer, [1] but can arise from any number of tissues including the prostate, [2] bladder, gallbladder, [3] breast, colon, [4] ovarian stroma and testis. [5]

2022年3月4日 · Signet-ring cells (SRCs) in effusion specimens represent a diagnostic challenge. In this study, a consecutive series of pleural and peritoneal effusions with benign SRCs are examined and compared with malignant SRCs. We reviewed consecutive Wright-stained serous effusion slides and searched for cases with SRCs.

2017年8月1日 · Signet ring cells (SRCs) can be seen in a variety of thyroid tumors and can pose a diagnostic pitfall on cytology. This study describes the cytologic, histomorphologic, and molecular aspects of a cohort of primary thyroid tumors with SRCs.

2022年6月10日，西湖大学施一公团队在 Science 上在线发表了题为“Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex”的最新研究成果，报道了目前分辨率最高的NPC中胞质环（CR）亚基的结构。

NPCs are organized into four main rings: the cytoplasmic ring (CR) at the cytosolic side, the inner ring and the luminal ring on the plane of the nuclear membrane, and the nuclear ring facing the nucleus. Each ring possesses an approximate eightfold symmetry and is composed of multiple copies of different nucleoporins.

2022年6月15日 · NPC被组装成四个主要的环：位于细胞质一侧的细胞质环（cytoplasmic ring, CR）、位于核膜平面上的内环（inner ring）和管状环（luminal ring）以及面向细胞核的核环（nuclear ring）。每个环都拥有近似八倍的对称性，由不同的核孔蛋白（nucleoporin, Nup）的多个拷贝组成。 NPC参与了许多生物过程，其功能障碍与越来越多的严重人类疾病有关。 然而，尽管过去二十年来许多研究小组进行了开创性的研究，但是人们仍然对NPC的组装、动态和复杂 …

"Signet ring cell" (SRC) is a phenotypic designation for a cell with a large clear cytoplasmic vacuole displacing the nucleus to the periphery. Our study focuses on the cytopathologic significance of SRCs in the context of diagnostic range, ancillary studies, and clinical prognosis.

At the cytokinesis cleavage furrow, it is the actin-myosin contractile ring that drives the cleavage process, during which cell membrane and wall grow inward, which eventually pinches the mother cell in two. The key components of this ring are the …