2017年8月28日 · 该蛋 白激酶能够有效激活有丝分裂原活化蛋 白激酶 (mitogen-activatedproteinkinase，MAPK)和NF—xB信号通路 ，与多种肿瘤 的发生与发展密切相关 。 本文将从其 结构、蛋 白磷酸化、信号传导、免疫调节及与肿瘤 的关系等方面对 MEKK3的研究进行相 …

2001年7月1日 · Using mitogen-activated protein kinase kinase kinase 3 (MEKK3)-deficient fibroblast cells, we found that MEKK3 plays a critical role in TNF-induced NF-κB activation. We have shown that MEKK3 is...

肿瘤坏死因子通过使caspase-8与FADD结合而诱导凋亡，并促进炎症和存活，这是通过TRAF2经由JNK依赖性激酶级联，MEKK激酶级联和RIP激活NF-kB介导的。 三 肿瘤坏死因子（TNF）在肿瘤微环境中的促肿瘤作用

A new member of the MEKK family (MEKK-3) has recently been found to associate with RIP, meaning that it could potentially play a role in downstream survival signaling. Indeed, disruption of MEKK-3 severely impairs the activation of NF-κB induced by TNF, and MEKK-3-/-cells are highly sensitive to TNF-induced apoptosis . The IκB kinase complex

新型 61-kda 蛋白激酶 rip2 与 rip 有关，后者是 tnfr1 的组分，介导半胱天冬酶死亡蛋白酶的募集。 RIP2 过表达同时发出 NF-KappaB 活化和细胞死亡的信号 ( 3, 5-9 )。

TRAF2 (TNF Receptor-Associated Factor-2) has been implicated in the activation of two distinct pathways that leads to the activation of Activation Protein-1 via the JNK (Jun NH2-terminal Kinase), MEKK (MEK Kinase), p38 and, together with RIP, NF-KappaB activation, via the NIK (NF-KappaB-Inducing Kinase).

Representative images of (M) wound healing assays and (N) transwell assays showed that MEKK1 repression or U0126 rescued the enhanced invasion and migration ability by overexpression of IMP3 (* p <...

Using mitogen-activated protein kinase kinase kinase 3 (MEKK3)-deficient fibroblast cells, we found that MEKK3 plays a critical role in TNF-induced NF-kappaB activation. We have shown that MEKK3 is required for IKK activation and functions downstream of receptor-interacting protein (RIP) and TNF receptor- associated factor 2.

2001年8月1日 · We demonstrate here that ectopically expressed RIP induces I-kappaB kinase-beta (IKKbeta) activation in intact cells and that RIP-induced IKKbeta activation can be blocked by a kinase-inactive...

Download scientific diagram | RIP1 associates with the MAP3K MEKK3 in TNF-stimulated cells. (A) RIP1 interacts with MEKK3 and Tpl2 kinases. 293T cells were left untransfected (NIL) or transfected ...