Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. [5] [6] [7] The RNase H1 is a non-specific endonuclease and catalyzes the …

2024年12月25日 · This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start …

2022年9月1日 · 真核RNase H1则具有N端线粒体靶向序列 (MTS)，该蛋白以两种亚型表达，分布定位于细胞核和线粒体。 此外，真核RNase H1还包含一个额外靠近N端的约50个氨基酸区 …

RNase H1 has become an essential tool to uncover the physiological and pathological roles of R-loops, three-stranded structures consisting of and RNA-DNA hybrid opposite to a single DNA …

核糖核酸酶 H1： 该基因编码一种核酸内切酶，可特异性降解 RNA-DNA 杂交体的 RNA，并在 DNA 复制和修复中发挥关键作用。 交替的框内起始密码子起始导致产生指向线粒体或细胞核的 …

2025年2月9日 · RPA is a sensor of R loops and a regulator of RNaseH1, extending the versatile role of RPA in suppression of genomic instability. RNaseH1 maintains regulated levels of …

2025年2月9日 · RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells. Arora R, et al. Nat Commun, 2014 Oct 21. PMID 25330849, Free PMC …

RNase H1 is present in prokaryotes and eukaryotes and cleaves RNA in RNA/DNA hybrids. Its main function is hybrid removal, notably in the context of R-loops. RNase H2, which is also …

2019年12月1日 · RNase H1 is present in prokaryotes and eukaryotes and cleaves RNA in RNA/DNA hybrids. Its main function is hybrid removal, notably in the context of R-loops. …

Our studying suggests that RNASEH1 is a potential cancer biomarker. And RNASEH1 may be able to regulate the tumor microenvironment by regulating the relevant physiological activities …