2024年12月25日 · RNASEH2A (Ribonuclease H2 Subunit A) is a Protein Coding gene. Diseases associated with RNASEH2A include Aicardi-Goutieres Syndrome 4 and Aicardi-Goutieres Syndrome. Among its related pathways is Pathways of nucleic acid metabolism and innate immune sensing.

RNaseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to …

2022年12月28日 · In this study, we revealed that the expression of RNaseH2A, which removes ribonucleoside monophosphates (rNMPs) from the genome, is regulated by E2F transcription factors, and it decreases during...

RNAseH2 是哺乳动物细胞中核糖核酸酶 H 活性的主要来源，并以内切核酸酶的方式切割核糖核苷酸。 预计在滞后链 DNA 合成过程中去除冈崎片段 RNA 引物，并从 DNA-DNA 双链体中切除单个核糖核苷酸。 该基因的突变导致 Aicardi-Goutieres 综合征 (AGS) ，这是一种常染色体隐性遗传性神经系统疾病，其特征是进行性小头畸形和精神运动迟缓、颅内钙化、脑脊液中干扰素-α 和白细胞水平升高。 [RefSeq 提供， 2009 年 8 月] The protein encoded by this gene is a component …

2025年2月8日 · RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to …

RNASEH2A silencing substantially decreased the proliferation, clone formation capacity, migration, and invasion, while increasing apoptosis in GC cells ( p < 0.05). Conclusions: Our results indicate that RNASEH2A can promote GC cell proliferation, migration, and invasion, while inhibiting apoptosis, thereby contributing to the emergence of GC.

The RNASEH2A gene provides instructions for making one part (subunit) of a group of proteins called the RNase H2 complex. This complex is a ribonuclease, which means it is an enzyme that helps break down molecules that contain RNA, a chemical cousin of DNA.

2018年9月14日 · By transient expression in HEK293T cells, Crow et al. (2006) showed that the human RNASEH2A, RNASEH2B, and RNASEH2C genes interact with each other and form an enzymatic protein complex with RNase H2 activity. The complex was able to recognize and cleave a single ribonucleotide embedded in a DNA-DNA complex.

2025年2月8日 · RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. An RNase H2 mutant lacking ribonucleotide excision repair activity but supporting R-loop removal revealed that ribonucleotides in DNA initiate p53-dependent DNA damage response and early embryonic arrest in mouse.

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.