2024年2月1日 · Normal ROS levels are essential for cellular processes, known as oxidative eustress. Oxidants activate ASK1, JNK, p38 and ERK MAPKs, and PI3K/Akt signaling pathways. Oxidants activate transcription factors like Nrf2, HIF-1α, AP-1, NF-κB, FoxO and p53. Keap1 contains distinct sets of sensor Cys residues that sense diverse Nrf2 inducers.

ASK1 是一种广泛表达的氧化还原敏感性丝氨酸/苏氨酸激酶，可激活 p38 和 c-Jun N 末端激酶 (JNK)MAPKKs，并诱导细胞凋亡，炎症和纤维化信号传导。 在氧化应激状态下 ASK1 激活 JNK，从而抑制 MEKK1、NF-κB 活性，使细胞从生存走向死亡，相反，在还原状态下硫氧还蛋白 (Trx) 通过 MEKK1-JNK 激活 NF-κB，结合并抑制 ASK1 使细胞偏向于生存的途径。 研究人员利用药物高通量筛选发现了一种新型 ASK1 抑制剂，并对其结构进行改进以提高对 ASK1 的有效 …

2005年5月1日 · ASK1 formed a complex with TRAF6 in response to LPS, and this complex formation and subsequent ASK1 activation required LPS-induced production of reactive oxygen species (ROS). Thus,...

2004年12月9日 · Reactive oxygen species (ROS), nitric oxide and endoplasmic reticulum (ER) stress have been implicated in A β -induced neurotoxicity. We have reported that apoptosis signal-regulating kinase 1...

2019年1月24日 · Our findings demonstrate a non-autonomous activation of a ROS sensing mechanism by Ask1 and Akt1 to replace the missing tissue after damage. Collectively, these results provide the basis for understanding the molecular mechanism of communication between dying and living cells that triggers regeneration.

2006年4月1日 · ASK1 is activated in response to various stimuli including LPS, ROS, ER stress, influx of calcium ions and various cytokines such as tumor necrosis factor and Fas ligand. We have recently demonstrated that the TRAF6–ASK1–p38 axis is essential for inflammatory response on LPS stimulation.

2014年1月21日 · Apoptosis signal–regulating kinase 1 (ASK1, also known as MAP3K5) mediates reactive oxygen species (ROS)–induced cell death. When activated by ROS, ASK1 ultimately becomes ubiquitinated and degraded by the proteasome, a process that is antagonized by the ubiquitin-specific protease USP9X.

2023年12月15日 · ASK1 activity is triggered in response to multiple stressors, including endoplasmic reticulum (ER) stress, lipopolysaccharides (LPS), calcium influx and tumor necrosis factor α (TNF-α), and reactive oxygen species (ROS) stress, and its dysregulation is involved in the pathogenesis of a variety of diseases, including tumor growth and tumor ...

2019年8月5日 · Inhibition of ROS with N-acetyl cysteine (NAC) significantly decreased pristimerin-induced cell death by inhibiting the phosphorylation of ASK1 and JNK. Taken together, these results suggest a critical role for the ROS/ASK1/JNK …

Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. Here we used ASK1-deficient mice to show that ASK1 was selectively required for lipopolysaccharide-induced activation of p3 …