2022年10月22日 · 大量研究表明，以线粒体通透性转换孔（mptp）开放和活性氧（ros）水平升高、线粒体膜电位（mmp）降低为表现的线粒体功能障碍在神经性疼痛的发生发展中起重要作用。

2022年4月14日 · Mori et al. now identify ATP and reactive oxygen species (ROS) as key upstream cues for cell extrusion. Extrusion of transformed cells involves their competition with their normal,...

2023年12月11日 · In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are regarded as the...

2019年6月11日 · Mitochondria are critical for the function and maintenance of myelinated axons notably through Adenosine triphosphate (ATP) production. A direct by-product of this ATP production is reactive oxygen species (ROS), which are highly deleterious for neurons.

线粒体呼吸链 是能量产生的核心，因为它将呼吸链复合物之间的电子转移与穿过线粒体内膜的质子传递相结合，以产生 ATP 合成所需的电化学梯度。 除了对能量产生至关重要外，呼吸链还是细胞内 ROS 的主要来源，ROS是作为电子转移的副产品产生的（图1）。 尽管每个复合物中产生 ROS 的确切位点及其产生机制尚未完全阐明，但复合物 I（NADH：泛醌氧化还原酶）和 III（泛醇：细胞色素 c 氧化还原酶）被认为是呼吸链中 ROS 的主要来源。 对于复合物 I，超氧化物的产生 …

The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP generation. Calcium is a key regulator of mitochondrial function and acts at several levels within the organelle to stimulate ATP synthesis. However, the dysregulation of mitochondrial Ca(2+) homeostasis is no …

2020年10月1日 · The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation. A consequence of electron transfer is the generation of reactive oxygen species (ROS), which contributes to both homeostatic signaling as well as oxidative stress during pathology.

In addition to the production of energy in the form of ATP, mitochondria play a crucial role in the entire cell physiology through their participation in many metabolic and signaling pathways. Mitochondria are able to monitor their surrounding environment, including intracellular ATP, oxygen, ROS, Ca 2+, growth factors, etc. These organelles ...

在真核细胞中，ATP 生成通常被视为常氧条件下线粒体的主要功能。 相比之下，活性氧（ROS）被认为是呼吸的副产品，与功能障碍和疾病广泛相关。 近年来，线粒体 ROS 的重要信号传导功能已被证实。 尽管如此，它们的化学反应性和引发氧化损伤的能力强化了这样的观点：ROS 是疾病期间积累的功能失调的线粒体的产物。 然而，一些研究支持不同的模型，表明： (1) 有限的氧气可用性导致线粒体优先考虑 ROS 产生而不是 ATP， (2) ROS 是由各种重要应激源触发的 …

Mitochondria are important sites for the production of ATP and the generation of ROS in cells. However, whether acute hypoxia increases ROS generation in cells or affects ATP production remains unclear, and therefore, monitoring the changes in …