In the endoplasmic reticulum (ER), hydrogen peroxide (H 2 O 2), a non-radical ROS, is produced through the process of oxidative folding. Utilisation and dysregulation of H 2 O 2, in particular that generated in the ER, affects not only cellular homeostasis but also the longevity of organisms.

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative stress refers to the imbalance due to excess ROS or oxidants over the capability of the cell to mount an effective antioxidant response.

2021年4月16日 · We show that pharmacological or genetic manipulations that increase mtH2O2 levels lead to increased FLP-1 secretion that is dependent upon ROS dismutation, mitochondrial calcium influx, and ...

2020年3月30日 · Two species, hydrogen peroxide (H2O2) and the superoxide anion radical (O2·−), are key redox signalling agents generated under the control of growth factors and cytokines by more than 40 ...

Among ROS, O 2•− is the primary oxygen radical produced through the one-electron oxygen reduction. Superoxide dismutase (SOD) converts O 2•− into hydrogen peroxide (H 2 O 2), serving as a precursor for other ROS. Through the Haber-Weiss reaction, O 2•− generates HO •, a highly reactive ROS within the cell.

2021年1月25日 · Here we review the organelle-specific ROS-generating and consuming pathways, providing evidence that the ER is a major contributing source of potentially pathologic ROS.

2011年10月6日 · It is now evident that at lower physiological levels, H 2 O 2 can act as a classical intracellular signalling molecule regulating kinase-driven pathways. The newly discovered biological functions...

Reactive oxygen species (ROS) were seen as destructive molecules, but recently, they have been shown also to act as second messengers in varying intracellular signaling pathways. This review concentrates on hydrogen peroxide (H2O2), as it is a more stable ROS, and delineates its role as a …

2015年5月11日 · 与ROS相关的药物的作用机理提供理论支持。 本研究的主要结论如下： 1．描述三种检测细胞内H202的探针的性质和生物学应用。通过共聚焦荧光. 显微镜分析等方法比较三种探针的灵敏性、细胞内分布、细胞内H202浓度的动

2015年9月14日 · Hydrogen peroxide (H 2 O 2) is next to the superoxide anion and hydroxyl radical a key member of the class of reactive oxygen species (ROS), which are in particular generated via the respiratory chain cascade but also as byproducts of the cellular metabolism including protein folding.