Reactive oxygen species and hematopoietic stem cell senescence
This review aims to provide a summary of a number of recent findings regarding the cellular sources of ROS in HSCs and the mechanisms of action whereby ROS induce HSC …
Oxidative resistance of leukemic stem cells and oxidative …
2020年4月27日 · Under hypoxia, the dynamic balance between the generation and clearing of intracellular reactive oxygen species (ROS) is conducive to maintaining a quiescent state of …
Oxidative stress and hypoxia in normal and leukemic stem cells
2016年7月1日 · The low energetic oxidative metabolism existing in HSCs results in a low production of endogenous reactive oxygen species (ROS). Low ROS production in HSCs is …
The Dual Role of ROS in Hematological Malignancies: Stem Cell ...
Targeting genes involved in ROS in LSCs and HSCs are increasingly being used as a critical target for therapeutic interventions. Appropriate concentration of ROS may be an optimal …
Reactive oxygen species and hematopoietic stem cell senescence
Increased levels of ROS are produced by mitochondria and/or NADPH oxidases (NOXs) in HSCs when HSCs are exposed to stress, a high concentration of oxygen or after deletion of ATM, …
Nynrin preserves hematopoietic stem cell function by inhibiting …
2024年9月5日 · Reserving low ROS levels within HSCs is pivotal for maintaining quiescence and preventing premature cellular differentiation. Genetic studies have revealed that deleting …
Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self …
Intracellular reactive oxygen species (ROS) regulate self renewal versus activation of hematopoietic stem cells (HSCs). Quiescent, long-term repopulating stem cells are …
Selenoprotein-mediated redox regulation shapes the cell fate of HSCs …
2025年3月13日 · Accumulation of ROS stands out as a hallmark of aged hematopoiesis. 1 We observed downregulation of mRNA for key antioxidant selenoproteins in aged human HSCs …
Stress-protecting harbors for hematopoietic stem cells
2024年2月1日 · Reactive oxygen species (ROS) play crucial roles in regulating HSC repopulation, quiescence, self-renewal, and apoptosis [19]. Studies have demonstrated that ROS can …
The Dual Role of ROS in Hematological Malignancies: Stem Cell ...
Background and objective: Reactive oxygen species (ROS) play crucial role in hematopoiesis, regulation of differentiation, self-renewal, and the balance between quiescence and …