In cultured cells, an increase in cellular levels of reactive oxygen species (ROS) can be detected using multiple techniques including colorimetric assays, immunoblotting, and …

ROS1 rearrangements can be detected using fluorescence in situ hybridization (FISH); however, immunohistochemistry (IHC) for ROS1 protein is a promising alternate screening modality. In …

4 天之前 · Monoclonal Antibody for studying ROS. Validated for F, IF, IHC, IP, WB, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, ROS1 (D4D6®) Rabbit …

2013年11月1日 · Recently, immunohistochemical analyses using a novel anti-ROS1 rabbit monoclonal antibody (D4D6) have shown promise for accurate identification of ROS1 …

2020年12月1日 · IHC stains with lower ESS correlated with increased error rates in ALK and ROS1 interpretation and analysis failures. Laboratory characteristics differently affected …

2016年7月1日 · This study confirms that IHC staining for ROS1 protein within the cytoplasm of tumor cells can potentially be used as a screening tool for ROS1 gene rearrangements, with …

2019年12月1日 · We have evaluated a novel anti-ROS1 IHC antibody (SP384) in a large multicenter series to obtain real-world data. A total of 43 ROS1 FISH–positive and 193 ROS1 …

ROS1 immunohistochemistry has been proposed as a cost-effective screening test for detection of ROS1 rearrangement. Most studies about the correlation between ROS1 FISH and …

Of the IHC scoring methods examined, staining in the cytoplasm of 2+ or above in more than 30% of total tumor cells considered as IHC positive had the highest correlation with a FISH-positive …

IHC is a reliable and rapid screening tool in routine pathologic laboratories for the identification of suitable candidates for ROS1-targeted therapy. Some ROS1 IHC-positive but FISH-negative …