Sarsasapogenin (SAR, Parigenin)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。 SAR能够有效地抑制 NF-κB 和 MAPK 的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。

2021年5月13日 · We critically assess the value of ROS inhibitors with different mechanisms-of-action, including their potency, mode-of-action, known off-target effects, and clinical or preclinical status, while suggesting future avenues of research in the field.

NAC (N -acetyl- l -cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified inhibition of proteasome inhibitors as a novel activity of NAC.

2013年9月1日 · NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified inhibition of proteasome inhibitors as a novel activity of NAC.

Here, we categorized ROS1 TKIs by their structures (cyclic versus noncyclic) and inhibitory abilities (active against solvent front mutation G2032R or central β-sheet #6 [Cβ6] mutation L2086F) and summarized their reported clinical activity in order to provide a dashboard on how to use these ROS1 TKIs in various clinical situations.

2023年10月26日 · This knowledge will facilitate inhibitor-based approaches to modulate or suppress NOX signaling without compromising on nonspecific ROS-scavenging or antioxidant effects.

Over the past two decades, research efforts have focused on developing specific ROS inhibitors, resulting in a wide range of compounds with varying levels of specificity. These inhibitors can be classified into non‐selective inhibitors, selective inhibitors, and inhibitors with an unknown mode of action/specificity.

2023年12月1日 · The possible ROS pathways are NF-κB, MAPKs, PI3K-Akt, and the Keap1-Nrf2-ARE signaling pathway. This review covers the literature pertaining to the possible ROS pathways and strategies to inhibit them. Additionally, this review summarizes the literature related to …

mitotempo是一种线粒体靶向抗氧化剂，通过清除线粒体内的ros来直接抑制线粒体ros的产生。 它对线粒体ROS的作用为抑制该细胞器内的ROS生成提供了直接途径。

we briefly outline the major sources of cellular ROS production and comprehensively review the targeting of these by small molecule inhibitors. We critically assess the value of ROS inhibitors with different mechanisms-of-action, including their potency, mode-of-action, known off-target