2017年12月6日 · Here, we show a role for nitric oxide synthase (iNOS)- and NOX1-produced ROS in maintaining homeostasis of the gut microbiota. In vivo imaging revealed distinctly high levels of ROS in the...

2020年1月1日 · iNOS is important enzyme that utilizes oxygen to generate nitric oxide (NO) under stress conditions. Accumulating evidence indicate that iNOS-derived NO has a high impact on the metabolic response. INOS-derived NO greatly affect the whole body glucose and lipids metabolism via different mechanisms.

2018年5月1日 · Here, we show a role for nitric oxide synthase (iNOS)- and NOX1-produced ROS in maintaining homeostasis of the gut microbiota. In vivo imaging revealed distinctly high levels of ROS in the ileum of normal healthy mice, regulated in accordance with the amount of gut bacteria.

2004年10月1日 · ROS and RNS are important molecules in host innate immunity. The author briefly reviews the diseases that occur when these molecules cannot be produced, including the roles of ROS in chronic...

2010年3月12日 · The effects of iNOS induction on ROS production were examined. Induction of iNOS expression in RAW264.7 cells with LPS (lipopolysaccharide; 1 microg/ml) causes a significant increase in PMA-induced chemiluminescence, which could be enhanced by the NOS substrate, L-arginine, and could be abolished by the NOS inhibitor, L-NNA (NG-nitro-L-arginine).

Cellular senescence is an outcome of the accumulation of DNA damage which induces the growth arrest in cells. Physiologically, it is presumed to be mediated by accumulation of reactive oxygen species (ROS). Here, we show that another free radical, nitric oxide (NO) produced during inflammation or pr …

2017年1月1日 · Here step (1) represents ATM kinase mediated suppression of ROS induction, which maintains cell viability; step (2) represents ROS mediated iNOS induction which strengthens the DDR and maintains senescence and step (3) represents quenching of ROS thorough reaction with NO, by forming peroxynitrite (ONOO −) which is short lived. The middle ...

Here, we have found evidence for a high NOX1- and iNOS-dependent ROS production in the ileum of normal healthy mice. We furthermore observed a strong impact of this ROS

Reactive oxygen species (ROS) are well characterized as part of the innate phagocytic immunity; however, a role in controlling microorganisms in the gut lumen is less clear. Here, we show a role for nitric oxide synthase (iNOS)- and NOX1-produced ROS …

细胞衰老是DNA损伤积累的结果，DNA损伤会诱导细胞生长停滞。 从生理上讲，它被认为是由活性氧（ROS）的积累介导的。 在这里，我们显示出炎症过程中产生或作为环境污染物存在的另一种自由基一氧化氮（NO）也可以诱导细胞衰老。 在原代细胞和各种永生化细胞系中，通过外部添加或通过iNOS表达内部产生的慢性NO暴露导致DNA损伤反应的激活并引起细胞衰老。 由NO产生的表型包括强大的生长停滞，DNA损伤灶水平升高，ROS，SAβ-gal染色和炎性细胞因子（如IL …