2024年5月31日 · More importantly, the heat generated by PPy-KLA-Cu nanoparticles from NIR irradiation could enhance the nanozymatic activities for ROS elevation and increase the KLA-induced anticancer activity via mitochondrial dysfunction, realizing multimodal treatment of cancer cells with improved therapeutic efficacy.

A hybrid of IL4RPep-1 and 37 a pro-apoptotic peptide (KLAKLAK)2 (named IL4RPep-1-KLA) induced cytotoxicity and 38 apoptosis in KKU-213 cells and increased those levels induced by 5-fluorouracil...

一种新型的表观遗传修饰—— 组蛋白赖氨酸乳酸化 （Kla）被证实存在，且组蛋白Kla在缺氧，干扰素（IFN）-γ，脂多糖（LPS）或细菌攻击刺激的细胞中的基因启动子上积累以产生乳酸，从而直接调控基因表达。 组蛋白Kla已被证明促进肿瘤的发展 (图3)，乳酸介导的代谢基因表达通过组蛋白Kla的变化诱导肿瘤细胞摄取葡萄糖。 组蛋白Kla实现了乳酸介导的信号传导的目标，以支持肿瘤生长。 组蛋白Kla调节肿瘤相关基因（如YTHDF2）的转录，继而促进下游肿瘤抑制因子的降解 …

2017年1月9日 · As a result, G3-C12-HPMA-KLA disrupted the mitochondrial membrane, increased the generation of reactive oxygen species (ROS) and induced cytochrome c release, which ultimately resulted in...

2020年1月18日 · Conjugation of cell-penetrating peptides to anticancer peptides is an effective strategy to enhance tumor treatment. The hybrid peptide, kla-TAT, by attaching the TAT peptide to the C-terminus of the pro-apoptotic peptide kla exhibited strong anticancer activity when co-administration with other peptide, but the systematic mechanism was not clear.

2024年4月10日 · With the development of high-resolution liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), the lactate-derived, lysine lactylation (Kla), has been identified. Kla can alter the spatial configuration of chromatin and regulate the expression of corresponding genes.

2018年2月3日 · In this study, a peptide–peptide co-administration therapy between hybrid peptide kla-TAT and cationic anticancer peptide HPRP-A1 was designed to increase the anticancer activity of the combination peptides through synergistic effect. kla is a pro-apoptotic peptide which could induce rapid cancer cell apoptosis by disruption the mitochondrial ...

2022年4月9日 · PAMPm-co-PPBEn由亲水性阳离子AMP接枝聚合物（PAMP）和疏水性活性氧（ROS）敏感的苯硼酸酯接枝聚合物（PPBE）组成。 通过将这两种聚合物在水溶液中混合，形成了核-壳结构的纳米颗粒。 以抗菌肽KLA作为模型AMP进行研究。 在血液循环和正常组织（pH 7.4）中，纳米颗粒保持稳定，并将KLA埋入内部（非活性模式，Inactive Mode），从而抑制KLA的膜溶解能力，表现为低蛋白吸附（图2a），低溶血毒性（图2b）以及对正常组织细胞无毒（ …

2024年8月1日 · Kla, arising from the enzymatic conversion of lactate, the end-product of glycolysis, into lactyl-CoA has emerged as a crucial factor in regulating cellular processes. Its study initially focused on macrophages, and revealed the pivotal role of Kla in orchestrating the phenotypic shift from proinflammatory to tissue-repair states [1, 2 ...

聚阳离子肽（KLAKLAK）（2）作为一种可能的线粒体破坏剂，称为KLA（I型）或Kla（d型），具有抗癌活性，可通过与七精氨酸细胞传递载体融合来提高r7和R7（分别是肽r7-kla和R7-KLA），如文献所示。