一、线粒体膜电位（mmp）介绍线粒体是动植物细胞生成atp的主要地点，是促进细胞能量转换、参与细胞凋亡的重要细胞器。 线粒体在呼吸氧化过程中，将所产生的能量以电化学势能储存于线粒体内膜，在内膜两侧造成质子及…

In this chapter, we describe a relation between mitochondrial membrane potential and the rate of ROS formation. We present different methods applicable for isolated mitochondria or intact cells. We also present experiments demonstrating that a magnitude and a direction (increase or decrease) of a change in mitochondrial ROS production depends ...

基质金属蛋白酶（MMPs），1962年首先被确定为一种胶原蛋白水解酶，在蝌蚪尾巴的吸收过程中导致ECM蛋白降解。 属于metzincins超家族，是一类锌依赖性内肽酶，可降解ECM的各种蛋白质组分。 (一) MMP家族结构特点. 在脊椎动物中，MMP家族由28个成员组成，至少23个在人体组织中表达，其中14个在脉管系统中表达。 基质金属蛋白酶通常根据其底物和其结构域的组织结构分为胶原酶（collagenases）、明胶酶（gelatinases）、溶血素（stromelysins）、基质溶 …

2018年10月3日 · Here, we report a molecular axis, comprising the molecular adaptor hydrogen peroxide-inducible clone-5 (HIC-5), NADPH oxidase 4 (NOX4), and mitochondria-associated reactive oxygen species (mtROS), that regulates MMP9 expression and may be a target to suppress cancer metastasis.

2022年10月22日 · 大量研究表明，以线粒体通透性转换孔（mptp）开放和活性氧（ros）水平升高、线粒体膜电位（mmp）降低为表现的线粒体功能障碍在神经性疼痛的发生发展中起重要作用。

2020年7月20日 · ROS and the stress kinase JNK mediate the accumulation of matrix metalloproteinase 2 (Mmp2), damaging the BM, which recruits macrophages to the tissue. We propose a model where macrophage...

Here, we report a molecular axis, comprising the molecular adaptor hydrogen peroxide-inducible clone-5 (HIC-5), NADPH oxidase 4 (NOX4), and mitochondria-associated reactive oxygen species (mtROS), that regulates MMP9 expression and may be a target to suppress cancer metastasis.

2017年8月14日 · Matrix metalloproteinase (MMP) is defined as an endopeptidase in the extracellular matrix (ECM), which plays essential roles in physiological processes such as...

2016年6月1日 · Putative mechanisms of ROS-induced MMP. ROS can directly oxidise components or regulators of the PTP such as F O F 1 ATPase, VDAC and ANT. ROS also induce p53- or JNK-mediated activation of CypD or of Bax/Bak oligomerisation. Through p53 or JNK activation, ROS inhibit anti-apoptotic Bcl-2 family members.

2006年4月1日 · MMP-1, MMP-2, MMP-7, and MMP-9 are activated by ROS through interactions with thiol groups, in which the thiol residue is converted by ROS to sulfinic acid. 26,27 Redox-sensitive MMP activation promotes collagen degradation and remodeling of extracellular matrix. MMPs are also critically involved in GPCR-mediated transactivation of growth ...