2014年3月19日 · Here we report a new Sod1 function in oxidative signalling: in response to elevated endogenous and exogenous reactive oxygen species (ROS), Sod1 rapidly relocates into the nucleus, which is...

To determine the role that specific reactive oxygen species play in microglial activation, the levels of SOD1 were manipulated in N9 murine microglia. Stable overexpression of SOD1 caused significant decreases in superoxide and nitric oxide production, with concurrent increases in hydrogen peroxide following LPS.

Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen peroxide. Superoxide anions are the intended product of dedicated signaling enzymes as well as the byproduct of several metabolic processes including mitochondrial respiration.

2013年11月8日 · SOD1-mediated ROS reduction is increased when SIRT5 is co-expressed. Furthermore, mutation of the SOD1 succinylation site inhibits the growth of lung tumor cells. These results reveal a novel post-translational regulation of SOD1 by means of succinylation and SIRT5-dependent desuccinylation, which is important for the growth of lung tumor cells.

2019年9月1日 · SOD1 is commonly known for its ROS scavenging activity, but recent work has uncovered additional roles in modulating metabolism, maintaining redox balance, and regulating transcription. This new paradigm of expanded SOD1 function raises questions regarding the regulation of SOD1 and the cellular partitioning of its biological roles.

2022年10月12日 · We propose a feasible mechanism for SOD1 filament formation in ALS from the wild-type SOD1, suggesting that overoxidized SOD1 is a triggering factor of sALS. Our findings extend our...

2007年1月1日 · In the present study, SOD1 activity was modulated in N9 microglial cells either via pharmacological inhibition with disulfiram or via stable overexpression of a human SOD1 clone, and the resultant effects of SOD1 manipulation on both intracellular and intercellular oxidative and inflammatory signaling were determined.

2021年1月15日 · SOD1 is a critical enzyme in maintaining ROS homeostasis in different cell compartments. SOD1 gene is highly and ubiquitously expressed, although its expression can be further induced by ROS-responsive transcription factors, such as NF-κB and AP1 [ 54 ].

2018年5月3日 · Herein, we report that superoxide dismutase 1 (SOD1) is a conserved component of the mechanistic target of rapamycin complex 1 (mTORC1) nutrient signaling. mTORC1 regulates SOD1 activity through reversible phosphorylation at S39 in yeast and T40 in humans in response to nutrients, which moderates ROS level and prevents oxidative DNA damage.

铜锌超氧化物歧化酶（Copper-zinc Superoxide Dismutase，SOD1）是胞内广泛存在的抗氧化酶，催化O2·-歧化为H2O2和O2，维持胞内活性氧物种（ROS）内稳态。 癌细胞的生长、增殖都依赖于适度高浓度的H2O2，高表达的SOD1维持癌细胞内较高水平的H2O2和ROS内稳态。