ROS exacerbate skin aging and inflammation, but also function as regulators of homeostasis in the human body, including epidermal keratinocyte proliferation. There are four ROS: superoxide (O 2•−), hydrogen peroxide (H 2 O 2), the hydroxyl radical (• OH), and singlet oxygen (1 O 2).

Consequently, skin is a target for the generation of reactive oxygen species (ROS) and oxidative stress. ROS play well established roles in the development of many diseases, including cancer, aging, atherosclerosis and cardiovascular diseases.

2021年7月27日 · An increasing evidence showed that the elevated ROS/RNS production, especially due to UV irradiation, are associated with pigmentation and aging in the skin. ROS/RNS play key roles in skin damage and melanogenesis signaling pathways, and they contribute to the oxidation and/or polymerization of pre-existing melanin or …

This review focuses on the assessment of the injury environmental factors cause to the skin, molecular mechanism of ROS in the skin aging, and the use of antioxidants to prevent that damaging and producing a protection against UV radiation from environmental factors.

In this review the overall effects of oxidative stress are discussed as well as the sources of ROS including the mitochondrial ETC, peroxisomal and ER localized proteins, the Fenton reaction, and such enzymes as cyclooxygenases, lipoxygenases, xanthine oxidases, and NADPH oxidases.

2023年2月13日 · Oxidative stress causes skin cellular senescence, inflammation, and cancer through two possible mechanisms: (1) ROS directly damage biomolecules, thereby causing oxidative damage; (2) ROS mediate cellular signaling pathways, thus affecting gene expression.

2017年12月20日 · ROSs, the most common free oxygen radicals, participate in a series of physiological and pathological skin processes. Here, we discussed the role of oxidative events in injury, repair, photoaging, and cutaneous disease development.

2021年10月6日 · Skin, the largest organ in the human body, is exposed to air pollutants, including diesel exhaust fumes, ultraviolet rays, food, xenobiotics, drugs, and cosmetics, which promote the production of ROS. ROS exacerbate skin aging and inflammation, but also function as regulators of homeostasis in the human body, including epidermal keratinocyte ...

2010年5月1日 · Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually discussed in relation to UV exposure.

2018年4月23日 · Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural balance toward a pro-oxidative state, resulting in oxidative stress.