Yap1 homologs mediate more than the redox regulation of the …
2020年5月1日 · Yeast Yap1 is a paradigmatic example of a specific mechanism used by eukaryotic cells to link ROS sensing and gene regulation. The activation of this transcription …
Mitochondrial stress activates YAP/TAZ through RhoA oxidation to ...
2024年1月15日 · Here, we show that increased YAP activity is associated with mitochondrial stress during liver injury; and this is required for secondary inflammation, promoting …
Overexpression of the transcription factor Yap1 modifies …
2014年10月31日 · Yap1 is needed for the detoxification of reactive oxygen species (ROS) caused by increased oxidative protein folding. Constitutive co-overexpression of PpYAP1 leads to …
Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 …
2014年5月8日 · Chaetocin-treated tumors exhibited heightened ROS, pATM, YAP1 and pJNK levels. Our study highlights the coordinated control of glioma cell proliferation and metabolism …
Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 ... - PubMed
2014年5月8日 · Our study highlights the coordinated control of glioma cell proliferation and metabolism by ROS through (i) ATM-YAP1-driven apoptotic pathway and (ii) JNK-regulated …
氧化应激诱导的 YAP1 表达受 NCE102、CDA2 和 BCS1 调节,The …
2024年8月5日 · 在氧化应激下，酵母激活蛋白 1 （Yap1p） 经历翻译后修饰，导致其核积累。 YAP1 通过促进许多抗氧化基因的转录，在氧化解毒中发挥关键作用。 在这项研究中，我们确 …
Yeast AP-1 like transcription factors (Yap) and stress response: a ...
Yap1 plays a pivotal role in mitigating metal-generated ROS, but its contribution to metal detoxification is not restricted to the induction of the cellular antioxidant defences. Indeed, …
Structural basis for redox regulation of Yap1 transcription ... - Nature
2004年8月19日 · Here we identify a redox-regulated domain of Yap1 and determine its high-resolution solution structure. In the active oxidized form, a nuclear export signal (NES) in the …
Yap1 and Skn7 genetically interact with Rad51 in response to …
2016年12月1日 · In this study, we employed mutant strains lacking Rad51, the homolog of E. coli RecA recombinase, and Yap1 or Skn7, two major transcription factors responsive to ROS, to …
Exosomes derived from ITGB1 modified Telocytes ... - ScienceDirect
2024年3月15日 · Silencing YAP1 attenuated the inhibitory effects of ITGB1 on LPS-treated TCs, indicating ITGB1's role in activating YAP1 phosphorylation to inhibit inflammatory factor and …