My lab studies all aspects of GPCR structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. Currently we are focused on members of the …

Bryan L. Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine. [1] He is recognized for his discoveries …

Welcome to the Roth Lab! The Roth Lab studies the structure and function of G-Protein coupled receptors (GPCRs). For more specific information check out our research page. The Roth lab …

Structure-guided design of a peripherally restricted chemogenetic system Cell. 2024 Nov 25:S0092-8674 (24)01275-3. doi: 10.1016/j.cell.2024.11.001. Online ahead of print. PMID: …

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. BL Roth, SC Craigo, MS Choudhary, A Uluer, FJ Monsma, Y …

TRUPATH measures heterotrimeric G protein dissociation by bioluminescence resonance energy transfer 2, or BRET2, between an alpha subunit-fused RLuc8 and gamma subunit-fused GFP2 …

2016年2月17日 · Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are now commonly used by neuroscientists to identify the circuitry and …

2023年11月22日 · Here, we review the molecular basis of opioid receptor signaling with a focus on the structures of opioid receptors bound to endogenous peptides or pharmacological …

2023年12月6日 · 近日，Tao Che和Bryan L. Roth两人梳理了阿片类受体信号传导的分子机制，特别关注内源性肽或药理剂与受体结合的结构特征。 这些研究成果不仅阐释了配体选择性的关 …

Roth BL, et al. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nature Neuroscience . PMID …