Roxindole (developmental code name EMD-49980) is a dopaminergic and serotonergic drug which was originally developed by Merck KGaA for the treatment of schizophrenia. [1][2][3] In …

Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for …

The putative, selective dopamine (DA) dopamine-2 autoreceptor agonist roxindole, which also exhibits serotonin-1A-agonistic and 5-hydroxytryptamine reuptake-inhibiting properties, was …

Roxindole exhibits potent, long-lasting and highly selective agonistic actions atpresynaptic DAD2re- ceptors without stimulating postsynaptic D2receptors even athigh doses …

Roxindole is a potent autoreceptor-"selective" dopamine agonist originally developed for the treatment of schizophrenic syndromes. The drug also inhibits 5-HT uptake and has 5-HT1A …

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants …

Roxindole: 一种5-HT1A receptor激动剂、D2 receptor激动剂、5-羟色胺重摄取抑制剂药物，由Merck Serono SA (默克雪兰诺有限公司)公司最早进行研发，目前全球最高研发状态为终止，作 …

Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole …

R oxindole is a potential antidepressant agent. The present study determined its affinity and agonist efficacy at recombinant human (h) dopamine hD2, hD3 and hD4 and serotonin (5-HT) …

Roxindole (EMD 49980, 5-hydroxy-3- [4- (4-phenyl-1,2,3,6-tetrahydropyridyl (1))-butyl (1)]-indole mesylate), a selective dopamine autoreceptor agonist and a potential antipsychotic drug, …