Coordination between Two Branches of the Unfolded Protein …
2018年8月16日 · RPAP2 reverses IRE1 phosphorylation, oligomerization, and RNase activation. This inhibits IRE1-mediated adaptive events, including activation of the cytoprotective …
Coordination between Two Branches of the Unfolded Protein …
2018年8月16日 · RPAP2 inhibits IRE1 activity in the face of unmitigated ER stress, aborting cytoporotective adaptation and promoting DR5-mediated apoptosis. Thus, coordination …
RPAP2 inhibits IRE1 activity in the face of unmitigated ER stress, aborting cytoporotective adaptation and promoting DR5-medi-ated apoptosis. Thus, coordination between the PERK …
科学家发现并揭示新的转录起始检查点——RPAP2负调控转录起始 …
研究团队发现细胞内存在一个与RNA聚合酶II（Pol II）紧密相互作用的蛋白——RPAP2，二者能够形成稳定的RPAP2-Pol II复合物，解析人源RPAP2-Pol II的高分辨结构，发现RPAP2蛋白结合 …
The Structure, Activation and Signaling of IRE1 and Its Role in ...
It has been proposed that the mechanism of IRE1 attenuation by PERK/RPAP2 aims to abort failed adaptation to ER stress and trigger apoptosis .
RPAP2 regulates a transcription initiation checkpoint by inhibiting ...
2022年4月26日 · RPAP2 prevents and disrupts Pol II-TFIIF interaction and impairs in vitro transcription initiation, suggesting a function in inhibiting PIC assembly. Loss of RPAP2 in cells …
Homeostasis control in health and disease by the unfolded protein ...
2024年11月5日 · This paper reveals that ER stress triggers apoptosis through cell-autonomous activation of DR5 and that during the adaptive phase of the UPR, IRE1 blocks PERK-driven …
Exploring the IRE1 interactome: From canonical signaling …
2024年4月1日 · Upon acute ER stress, PERK-prolonged activation leads to the phosphatase RPAP2 to interact and dephosphorylate IRE1, thereby decreasing its signaling (41). Another …
The integrated stress response engages a cell-autonomous, ligand ...
2025年2月15日 · Dampening pro-survival IRE1 signals by the phosphatase RPAP2 downstream of PERK during persistent ER stress switches the balance in favor of pro-apoptotic signaling …
RPAP2 RNA polymerase II associated protein 2 [ (human)]
2025年2月8日 · Coordination between two branches of the unfolded protein response determines apoptotic cell fate so that PERK attenuates IRE1 via RPAP2 to abort failed endoplasmic …