2020年12月4日 · Our findings indicate that the RPP1 resistosome acts as a pathogen effector–inducible holoenzyme for NAD + hydrolysis. The tetrameric RPP1 oligomeric structure provides an example of direct pathogen effector recognition by a plant NLR receptor and uncovers the mechanism of strain-specific recognition leading to NLR conformational activation.

拟南芥的RPP1是TNL类抗病蛋白的典型代表，主要由N端的TIR结构域、中间的NOD（Nucleotide binding oligomerization domain）结构域以及C端的亮氨酸重复（Leucine rich repeat，LRR）结构域组成。

RPP1(RECOGNITION OF PERONOSPORA PARASITICA1) 是拟南芥中的一个抗病基因座，包含一系列复杂的抗病基因簇，最早在拟南芥生态型Wassilewskija（Ws）中发现【6】。RPP1中的多个成员可以介导拟南芥对活体营养型卵菌(Hyaloperonospora arabidopsidis)的抗性。

2020年12月11日 · 拟南芥的RPP1是TNL类抗病蛋白的典型代表，主要由N端的TIR结构域、中间的NOD（Nucleotide binding oligomerization domain）结构域以及C端的亮氨酸重复（Leucine rich repeat，LRR）结构域组成。 ATR1是植物病原菌Hyaloperonospora arabidopsis分泌的一类效应蛋白，在病原菌侵染植物叶片的过程中分泌到植物叶片内，被拟南芥的RPP1识别后，可以引起ETI。 ATR1诱导RPP1抗病小体的形成.

2016年7月18日 · Here, we focus on RPP1, an NLR from Arabidopsis that recognizes the oomycete effector ATR1. Using transient co-expression of proteins in plants, we demonstrate that recognition of ATR1 stimulates RPP1 oligomerization. This interaction involves multiple domains of RPP1 and is critical for immune activation.

RPP1, an essential yeast gene encodes a 32.2-kD protein ortholog of the human scleroderma autoimmune antigen, Rpp30.

Sequencing of the Rpp1 locus identified three homologous nucleotide binding site-leucine rich repeat (NBS-LRR) candidate resistance genes between Sct_187 and Sat_064. Each candidate gene is also predicted to encode an N-terminal ubiquitin-like protease 1 (ULP1) domain.

1997年11月11日 · RPP1, an essential yeast gene encodes a 32.2-kD protein ortholog of the human scleroderma autoimmune antigen, Rpp30.

2016年7月18日 · Expression of the N-terminus of RPP1, including the Toll/interleukin-1 receptor (TIR) domain ("N-TIR"), elicited an effector-independent cell death response, and we used allelic variation in TIR domain sequences to define the key residues that contribute to this phenotype.

2018年11月19日 · Cosilencing of the Rpp1 candidates abrogated the immune response in the Rpp1 resistant soybean accession PI 200492, indicating that Rpp1 is a ULP1-NBS-LRR protein and plays a key role in the IR. Plants are a potential source of sugars and other nutrients to microbes in the environment.