2024年12月25日 · RPS15A (Ribosomal Protein S15a) is a Protein Coding gene. Diseases associated with RPS15A include Diamond-Blackfan Anemia 20 and Diamond-Blackfan Anemia. Among its related pathways are Peptide chain elongation and Nervous system development.

RPS15A is a novel causative gene for Diamond-Blackfan anemia. Our findings indicate that RPS15A promotes cell proliferation and migration in glioblastoma for the first time. RPS15A might play a distinct role in glioblastoma and serve as a potential target for therapy

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is …

2025年1月4日 · 本文将深入探讨RPS15A基因的功能、作用机制及其在生物体内的信号通路，并分析其与特定疾病的关系。通过详细解析，帮助读者更好地理解这一基因在细胞中的重要角色。 RPS15A基因的基本信息 RPS15A基因，全称为ribosomal protein S15a，位于染色体16p12.3上。

2024年12月25日 · RPS15 (Ribosomal Protein S15) is a Protein Coding gene. Diseases associated with RPS15 include Leukemia, Chronic Lymphocytic and Diamond-Blackfan Anemia. Among its related pathways are Peptide chain elongation and Nervous system development.

Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1. Kong L, et al. J Cell Biochem, 2020 Jan. PMID 31535410; RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway. Liu C, et al.

2017年12月15日 · Ribosomal protein s15a (RPS15A) plays a promotive role in the mRNA/ribosome interactions during early translation. Our previous study has found that inhibiting RPS15A...

2023年10月25日 · 研究构建了基于靶向核糖体大亚基蛋白（RPLs）和 核糖体小亚基 蛋白（RPSs）的 CRISPR SAM 系统模型，筛选ESCC转移中发挥关键作用的核糖体蛋白，结合qPCR、IHC等验证实验，发现高水平的RPS15与食管癌患者的淋巴结转移能力显著正相关，且与食管癌患者的不良预后有关；体内、外功能实验表明高水平的RPS15促进ESCC的进展与转移。 2.确定目标分子功能：RPS15选择性增强p38 MAPK和E2F通路相关基因的翻译效率. 通 …

2025年3月5日 · Our study indicates that RPS15A is highly expressed in PTC tissues and cells, and its expression level is positively correlated with that of GGCT. Furthermore, RPS15A interacts with GGCT, and silencing RPS15A results in an increase in p53 protein expression levels. Recent studies have revealed a new function of p53 in the regulation of ferroptosis.

Ribosomal protein S15A (RPS15A), which has been identified as a highly conserved 40S ribosomal protein, is essential for cell survival and proliferation. The present study evaluated the functional role of RPS15A in colorectal cancer (CRC), and our investigation found that RPS15A was highly expressed …