2024年12月25日 · RREB1 (Ras Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with RREB1 include Bladder Cancer and Scrotum Melanoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is HIVEP1.

RREB1, also known as HNT, FINB and LZ321, is a zinc finger transcription factor that is originally identified as a transcriptional activator of calcitonin in response to Ras signaling. The first isoform of RREB1 encodes 755 amino acids and contains four tandem C2H2-type zinc fingers 1.

2024年1月10日 · Here, we show that the transcription factor RREB1 (Ras-responsive element-binding protein 1) is essential for neuron survival in the mammalian brain. A spontaneous mouse mutation causing loss of a nervous system–enriched Rreb1 transcript is associated with progressive loss of cerebellar Purkinje cells and ataxia.

RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma.

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene. [5] [6] [7]

2021年4月30日 · Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor acting downstream of RAS signaling. Rreb1 has been implicated in cancer and Noonan-like RASopathies. However, little is known about its role in mammalian non-disease states. Here, we show that Rreb1 is esse …

2020年2月10日 · In a recent issue of Nature, Massagué and colleagues (Su et al., 2020) identify RAS-responsive element binding protein 1 (RREB1) as a critical integrator of TGF-β and Ras signals during both developmental and cancer EMT programs. TGF-β is a key inducer of EMT during various developmental and pathogenic EMT events.

Ras反应元件结合蛋白1 (RREB1)是锌指转录因子中的一员，广泛参与细胞增殖、转录调控和DNA损伤修复等生物学过程。 新发现揭示了 RREB1 作为转录抑制因子和转录激活因子对靶基因进行转录调控。 RREB1 的激活受 MAPK 通路调控。 我们总结了 RREB1 的靶基因并讨论了 RREB1 在癌症发展中的作用。 此外，越来越多的证据表明 RREB1 是 2 型糖尿病和肥胖症的潜在风险基因。 我们还回顾了 RREB1 作为黑色素瘤检测生物标志物的当前临床应用。 总之，RREB1 是一 …

该基因编码的蛋白质是一种锌指转录因子，可与基因启动子的 Ras 反应元件 (RRE) 结合。 已经表明，降钙素基因启动子含有一个 RRE，编码的蛋白质在那里结合并增加降钙素的表达，这可能参与 Ras / Raf 介导的细胞分化。 已发现该基因的多个转录变体编码几种不同的亚型。 [RefSeq 提供，2009 年 12 月] The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters.

3 天之前 · RREB1, comprising 15 zinc finger (ZF) domains, is a critical transcription factor downstream of the RAS/mitogen-activated protein kinase (MAPK) signaling cascade, which plays a significant role in integration of RAS and TGF-β signaling pathways. TGF-β-activated small mother against decapentaplegic (SMAD) transcription factors are recruited by ...