2024年12月25日 · RRN3 (RRN3 Homolog, RNA Polymerase I Transcription Factor) is a Protein Coding gene. Diseases associated with RRN3 include Neurodegeneration, Childhood-Onset, With Brain Atrophy and Treacher Collins Syndrome 1.

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene. [5][6][7]

Enables RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter.

2002年7月26日 · Significantly, neither dephosphorylated Rrn3 nor Rrn3 produced in Escherichia coli can restore transcription by extracts from cycloheximide-treated cells. These results suggest that the phosphorylation state of Rrn3 regulates rDNA transcription by determining the steady-state concentration of the Rrn3·RNA polymerase I complex within the nucleolus.

2013年3月29日 · The human homologue of yeast Rrn3 is an RNA polymerase I-associated transcription factor that is essential for ribosomal DNA (rDNA) transcription. The generally accepted model is that Rrn3 functions as a bridge between RNA polymerase I and the transcription factors bound to the committed template.

2011年10月1日 · Cell growth is regulated during RNA polymerase (Pol) I transcription initiation by the conserved factor Rrn3/TIF-IA in yeast/humans. Here we provide a structure-function analysis of Rrn3 based on a combination of structural biology with in vivo and in vitro functional assays.

2025年2月20日 · High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer. Depletion of Ebp1 expression in primary colon cancer cells inhibits cell proliferation, colony forming, and invasion in vitro as well as tumor formation in vivo and enhances cell sensitivity to irradiation.

2016年7月15日 · High level rRNA production relies on efficient binding of initiation factors to the rRNA gene promoter and recruitment of Pol I complexes containing initiation factor Rrn3. Here, we determine the...

2005年8月8日 · HGNC Approved Gene Symbol: RRN3. Cytogenetic location: 16p13.11 Genomic coordinates (GRCh38) : 16:15,060,022-15,094,335 (from NCBI) Eukaryotic ribosomal RNA (rRNA) genes are transcribed by an enzyme solely dedicated to that purpose, RNA polymerase I (Pol I; see 602000), and their expression is coordinated with cellular growth rate.

2025年2月8日 · Rrn3 regulates rDNA transcription by determining the steady-state concentration of the Rrn3.RNA polymerase I complex within the nucleolus. (RRN3) Enables RNA polymerase binding activity.