2015年3月1日 · We analyzed ex vivo the nature of MTB antigen-specific T-cell responses directed against the MTB secreted antigens Rv0288, Rv1886c, Rv3875, the antigens Rv2958c, Rv2957, and Rv0447c (intracellular, non-secreted enzymes) in blood from Korean patients with active tuberculosis (TB).

2013年3月26日 · We studied major histocompatibility complex (MHC) class I peptide-presentation and nature of the antigen-specific CD8+ T-cell response from South African tuberculosis (TB) patients with active TB. 361 MHC class I binding epitopes were identified from three immunogenic TB proteins (ESAT-6 [Rv3875], Ag85B [Rv1886c], and TB10.4 [Rv0288], including ...

针对结核分枝杆菌 (MTB) 的 T 细胞反应的性质和寿命对于有效遏制病原体很重要。 我们在体外分析了针对 MTB 分泌抗原 Rv0288、Rv1886c、Rv3875、抗原 Rv2958c、Rv2957 和 Rv0447c（细胞内非分泌酶）的 MTB 抗原特异性 T 细胞反应的性质结核病（TB）。

We studied major histocompatibility complex (MHC) class I peptide-presentation and nature of the antigen-specific CD8+ T-cell response from South African tuberculosis (TB) patients with active...

2015年3月1日 · We have previously designed a broad panel of MHC class I multimers covering seven different MHC alleles presenting epitopes from six different MTB-derived proteins: 19 the early expressed secreted antigens TB10.4 (Rv0288), Ag85B (Rv1886c), and ESAT-6 (Rv3875), as well as intracellular enzymes glycosyltransferase 1 (Rv2957), glycosyltransferase ...

Rv3874和Rv3875是结核分枝杆菌RD1区编码的主要毒力蛋白，在MTB的感染过程以及免疫逃逸过程中起重要的作用。 有研究报道，鞘脂和鞘脂代谢中间产物与巨噬细胞功能改变存在一定关联，而对于MTB毒力蛋白Rv3874和Rv3875对巨噬细胞代谢功能的影响未见报道。

2008年8月12日 · Two native proteins, Rv1986c and Rv3875, were selected on the basis of their secreted or transmembrane characteristics and relatively lower frequencies of predicted MHC class II epitopes.

这两种抗原分别是由Rv3874和Rv3875基因编码，可以排除BCG接种对LTBI的诊断干扰，降低了诊断的假阳性率，但他们均不属于结核分枝杆菌潜伏期表达的抗原，所以仍无法将LTBI人群从ATB患者中鉴别开来。

We studied major histocompatibility complex (MHC) class I peptide-presentation and nature of the antigen-specific CD8+ T-cell response from South African tuberculosis (TB) patients with active TB. 361 MHC class I binding epitopes were identified from three immunogenic TB proteins (ESAT-6 [Rv3875], A …

2022年8月30日 · Serodiagnosis involving polyclonal antibodies detection against an antigen of Mycobacterium tuberculosis (Mtb) in serum samples can be instrumental. In our study, Rv3874 and Rv3875 antigens were cloned, expressed, and purified individually and as a chimeric construct in Escherichia coli BL21.