Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. [5] [6] [7] In the process of cardiac calcium-induced calcium release, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions.

2024年12月25日 · RYR2 (Ryanodine Receptor 2) is a Protein Coding gene. Diseases associated with RYR2 include Ventricular Arrhythmias Due To Cardiac Ryanodine Receptor Calcium Release Deficiency Syndrome and Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy .

这些研究人员通过解析出RyR2在8种条件下的结构，揭示出人CaM对猪RyR2的调控机制。 apo-CaM和Ca2+-CaM结合在一个由手柄、螺旋和中心结构域形成的狭长裂缝中，但是它们的结合位点是不同的，但存在一定的重叠。

2022年5月20日 · Cardiac ryanodine receptor (RyR2) is a large Ca 2+ release channel in the sarcoplasmic reticulum and indispensable for excitation-contraction coupling in the heart....

The RYR2 gene provides instructions for making a protein called ryanodine receptor 2. This protein is part of a family of ryanodine receptors, which form channels that transport positively charged calcium atoms (calcium ions) within cells.

Ryanodine受体（RyR）是存在于 内质网 /肌浆网上（ER/SR）的一种钙释放通道。 它能迅速地将Ca2+从ER/SR中释放出来, 从而发挥一系列的 生理功能。 Ryanodine受体对保持胞内钙的平衡也起着重要作用。 RYR的活性受到多种物质的调控，诱导胞内 钙库 释放、升高胞内钙浓度、激发钙活化，对钙激活钾通道的开放、兴奋收缩耦连等多种生理功能的完成有重要意义。 RYR的活性受到许多 小分子 物质（如 [Ca2+]、 [Mg2+]、NO、 咖啡因 等）和一些 大分子物质 如 蛋白质 的调 …

The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an essential regulator of cardiac excitation–contraction coupling and intracellular calcium homeostasis. Mutations of the RYR2 are the cause of rare, …

RyR1 and RyR2 are crucial for E-C coupling in both skeletal and cardiac muscle, respectively. The action potential travels to transverse tubules (t-tubules) resulting in SR Ca 2+ release, either by mechanical coupling to DHPR in skeletal muscle (Rios and Brum 1987) or by Ca 2+ induced Ca 2+ release in cardiac muscle (Endo 1977).

2019年12月17日 · 2型ryanodine受体（RyR2）是在心肌细胞的肌质网（SR）膜中表达的钙（Ca2 +）通道，负责在兴奋-收缩偶联（ECC）过程中将Ca2 +从肌质网（SR）释放到细胞质中。 从生理学上讲，该通道的开放是响应于Ca2 +进入由L型电压门控Ca2 +通道（Cav1.2）介导的细胞而发生的，该过程通常称为钙诱导的钙释放（CICR）。 RyR2介导的Ca2 +释放是许多生物学过程的基础，从肌肉收缩到学习和记忆。 RyR2功能异常与多种严重疾病的病理学有关：RyR2的150多个 …

2025年2月8日 · RyR2 activity determines the potency of open-state blockers flecainide and R-propafenone for suppressing arrhythmogenic Ca2+ waves in cardiomyocytes. Flecainide (1 mum) rescues the RyR2-P2328S atrial arrhythmogenic phenotype by restoring compromised INa and lambda, changes recently attributed to increased sarcoplasmic reticular Ca(2+) release.