Ryanodine受体（RyR）是存在于内质网/肌浆网上（ER/SR）的一种钙释放通道。它能迅速地将Ca2+从ER/SR中释放出来, 从而发挥一系列的生理功能。Ryanodine受体对保持胞内钙的平衡也起着重要作用。

Ryanodine receptors (RyR for short) form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons. [1] There are three major isoforms of the ryanodine receptor, which are found in different tissues and participate in different signaling pathways involving calcium release from intracellular ...

Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum membrane and are responsible for the release of Ca 2+ from intracellular stores during excitation-contraction coupling in both cardiac and skeletal muscle.

2014年12月1日 · Ryanodine receptors (RyRs) are intracellular Ca 2+ release channels on the sarcoplasmic and endoplasmic reticula required for fundamental cellular functions in most tissues,...

The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously expressed in many types of cells and participate in a variety of important Ca2+ …

2018年2月1日 · Ryanodine receptor Ca 2+ release channels (RyR) are the largest intracellular ion channels known. The primary physiological role of the RyR is to provide a ligand-regulated pathway for the release of stored Ca 2+ to regulate a diverse array of cellular processes. This article highlights advances in RyR channel structure, shedding new light on ...

Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+) release channels required for the function of many organs including heart and skeletal muscle, synaptic transmission in the brain, pancreatic beta cell function, and vascular tone.

Ryanodine receptors (RyRs) are the largest ion channels presently known. They are very large (2.2 MDa) Ca channels that play a key role in excitation-contraction (EC) coupling [1, 2, 3, 4, 5]. RyRs are present in all animals [6, 7]. Three RyR isoforms have been identified in mammals: RyR1, RyR2 and RyR3.

The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously expressed in many types of cells and p...

2024年12月25日 · RYR1 (Ryanodine Receptor 1) is a Protein Coding gene. Diseases associated with RYR1 include Malignant Hyperthermia 1 and King-Denborough Syndrome. Among its related pathways are Activation of cAMP-Dependent PKA and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding.