S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. [3][4] Human S100A12, also known as calgranulin C, was first described in 1995. [5] The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.

2024年12月25日 · S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration.

S100A12, also known as Calgranulin C, MRP6, or EN-RAGE (extracellular newly identified receptor for Advanced glycation endproducts binding protein), is a calcium-binding pro inflammatory protein predominantly secreted by granulocytes .

c10 单核细胞表现出 s100a 家族基因（包括 s100a8 和 s100a12）的高表达和 hla-dr 的低表达，这与严重 covid-19 中 hla-dr 低 s100a 高的单核细胞相似。 值得注意的是，该亚群明显激活了与脓毒症患者临床预后恶化相关的基因，包括 PLAC8、RETN 和 CLU。

Recent studies have found that S100A12 has a high clinical diagnostic value in clinical diseases. This article reviews the structure and function of S100A12 and its research progress in inflammatory bowel disease, sepsis, systemic lupus erythematosus and other clinical diseases.

Increased serum S100A12 levels are associated with higher risk of acute heart failure in patients with type 2 diabetes. S100 calcium-binding protein A12 knockdown ameliorates hypoxia-reoxygenation-induced inflammation and apoptosis in human cardiomyocytes by regulating caspase-4-mediated non-classical pyroptosis.

2025年1月19日 · S100钙结合蛋白A12（S100A12），也被称为钙粒蛋白C（Calgranulin C），是一种在多种生物过程中发挥重要作用的蛋白质。 S100A12含有2个EF手的钙结合基团，这种结构特征使其能够与钙离子结合，从而发挥多种生物功能。

2023年11月27日 · As members of the S100 protein subfamily of myeloid-related proteins, S100A8, S100A9 and S100A12 play a crucial role in resisting microbial infection and maintaining immune homeostasis.

Human S100A12 is predominantly expressed and secreted by neutrophil granulocytes and, therefore, has been assigned to the S100 protein subfamily of calgranulins or myeloid-related proteins. Intracellular S100A12 exists as an anti-parallel homodimer and upon calcium-dependent activation interacts with target proteins to regulate cellular functions.

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，它们成簇地位于染色体 1q21 上。 该蛋白被认为参与特定的钙依赖性信号转导途径，其对细胞骨架成分的调节作用可能调节各种中性粒细胞活性。 该蛋白质包括具有抗菌活性的抗菌肽。 [RefSeq 提供，2014 年 11 月] The protein encoded by this gene is a …