2024年12月25日 · S100A4 (S100 Calcium Binding Protein A4) is a Protein Coding gene. Diseases associated with S100A4 include Follicular Adenoma and Anaplastic Thyroid Carcinoma. Among its related pathways are Vitamin D receptor pathway and Ca, cAMP and Lipid Signaling.

S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. Research demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via the RAGE receptor, in promoting endothelial cell migration by increasing KDR expression and MMP-9 ...

2022年2月9日 · Here, the authors identify molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and propose S100A4 as a regulator of immune...

While S100A4 has long been implicated mainly in tumorigenesis and metastatization, mounting evidence shows that S100A4 is a key player in promoting pro-inflammatory phenotypes and organ pro-fibrotic pathways in the liver, kidney, lung, heart, tendons, and synovial tissues.

2021年6月22日 · 该研究中，研究人员通过体内和体外实验发现，钙离子结合蛋白S100A4，又称为肿瘤转移因子（Metastasin），通过促进TAM对细胞外源脂肪酸的利用，提高线粒体依赖的FAO水平，从而控制了M2型TAM的代谢重编程及其向“促肿瘤”表型转化的进程。 S100A4-GFP报告基因小鼠移植瘤实验表明，S100A4阳性TAM为M2促肿瘤表型；全身系统性或髓样细胞特异性敲除小鼠S100A4后，移植瘤的TME中M2型TAM的比例显著降低，肿瘤生长明显受到抑制。 生化实验 …

7.S100A4是一个免疫治疗靶点 作者通过对MC3、MC4和MC5致瘤髓样细胞和TC4 (treg)和TC5 (衰竭T细胞)中的基因表达分析，寻找共同高表达的基因，发现S100A4是在TC4、TC5和致瘤髓细胞中高度表达的标志基因。

Fibroblast specific protein 1 (FSP1)/S100A4 is a calcium binding protein which has been linked to epithelial-mesenchymal transition, tissue fibrosis, pulmonary vascular disease, metastatic tumour development, increased tumour cell motility and invasiveness.

S100A4, an important member of S100 family proteins, functions to increase the tumor progression and metastasis. The molecular mechanisms of S100A4 involving in the progression and metastasis are diverse in various malignant tumors.

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been discovered as a potent factor implicated in various inflammation-associated diseases. S100A4 is involved in a range of biological functions such as angiogenesis, cell differentiation, apoptosis, motility, and inv …

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，它们成簇地位于染色体 1q21 上。 这种蛋白质可能在运动、侵袭和微管蛋白聚合中发挥作用。 该基因的染色体重排和表达改变与肿瘤转移有关。 已经鉴定出编码相同蛋白质的多个可变剪接变体。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene …