2024年12月25日 · S100A9 (S100 Calcium Binding Protein A9) is a Protein Coding gene. Diseases associated with S100A9 include Juvenile Rheumatoid Arthritis and Crohn's Disease. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

S100A9 is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes …

This review has a threefold purpose: 1) describe S100A9 structural elements important for its biological activity, 2) describe S100A9 biology in the context of the immune system, and 3) illustrate the role of S100A9 in the development of malignancy via interactions with the immune system and other cellular processes.

S100A9 属于S100 钙结合蛋白家族,是一种内源性损伤相关分子模式(DAMP)分子,在炎症和组织损伤中发挥重要作用[7]。 研究表明,S100A9 及其异二聚体是高级糖基化终产物受体(RAGE) 和Toll 样受体4 (TLR4) 的重要配体[8]。 S100A9释放后,可以促进炎症因子、趋化因子和纤维化标志物的表达,同时刺激成纤维细胞增殖,从而激活炎症反应和加速组织纤维化进程[9] [10]。 因此,本综述旨在阐明S100A9的生物学效应及其在纤维化疾病中的作用机制。 我们将重点讨论S100A9在调控炎症 …

2024年12月10日 · S100A8 and S100A9 are important drivers of tumorigenesis, tumor progression, metastasis, and resistance to anticancer therapies. • Serum concentrations or tissue expression levels of S100A8, S100A9, and S100A8/9 have been proven to be promising biomarkers for cancer diagnosis or prognosis prediction in various cancers. •

2025年3月8日 · Intracellular calprotectin (S100A8/A9) facilitates DNA damage responses and promotes apoptosis in head and neck squamous cell carcinoma. Serial measurement of circulating calprotectin as a prognostic biomarker in COVID-19 patients in intensive care setting.

2024年5月15日 · S100A9 regulates three fundamental mechanisms contributing to lung inflammation in infection. First, it increases the number of myeloid cells in circulation. S100A9 has been shown to induce the differentiation of acute myeloid cells and their growth arrest in human and mouse models of acute myeloid leukemia .

Forming a common heterodimer structure S100A8/A9, S100A8 and S100A9 are widely reported to participate in multiple signaling pathways in tumor cells. Meanwhile, S100A8/A9, S100A8, and S100A9, mainly as promoters, contribute to tumor development, growth and metastasis by interfering with tumor metabolism and the microenvironment.

S100A9 is an independent prognostic factor in GBM patients and is related to poor prognosis. It can be used as an effective tool to predict the response of GBM patients to immune checkpoint inhibitors (ICIs). In addition, S100A9 can promote the malignant progression of GBM and the migration of M2 macrophages.

2024年12月11日 · s100a9的表达与患者预后、肿瘤突变负荷、微卫星不稳定性和免疫细胞浸润密切相关。 研究认为S100A9在癌症进展中起着重要作用，可作为有价值的预后生物标志物和治疗靶点，调控其活性可能显著影响癌症管理策略。