S100B is a 21-kDa protein that is produced and secreted by astrocytes and widely used as a marker of brain injury in clinical and experimental studies. The majority of these studies are based on measurements in blood serum, <i>assuming</i> an associated increase in cerebrospinal fluid and a rupture …

S100B is a 21-kDa protein that is produced and secreted by astrocytes and widely used as a marker of brain injury in clinical and experimental studies. The majority of these studies are based on measurements in blood serum, assuming an associated increase in cerebrospinal fluid and a rupture of the blood–brain barrier (BBB).

S100B is a Ca 2+-binding protein mainly concentrated in astrocytes. Its levels in biological fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are recognized as a reliable biomarker of active neural distress.

2022年11月1日 · S100B is a small dimeric cytosolic and calcium-binding protein with a molecular size that ranges between 9 and 21 kDa. It is soluble in 100% ammonium sulfate liquid [71]. Its normal level in serum is 0.14 μg/l [72], and 1.8 μg/l in CSF [73]. Notably the S100B increase measured at the time of trauma correlates poorly with TBI outcome [74].

S100B has successfully been implemented in the clinic regionally (1) to screen mild TBI patients evaluating the need to perform a head computerized tomography, (2) to predict outcome in moderate-to-severe TBI patients, (3) to detect secondary injury development in brain-injured patients and (4) to evaluate treatment efficacy.

S100B is a small homodimeric protein consisting of two β subunits, with a molecular weight of ~21 kDa . It belongs to a multigenic family of Ca2+-binding proteins (i.e., regulators of intracellular levels of calcium) involved in a variety of intracellular and extracellular activities, including neuronal differentiation, survival and ...

2023年4月1日 · S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. In addition to its use as a diagnostic biomarker, S100B plays an active role in the molecular pathogenic processes accompanying acute …

2011年3月18日 · S100B is a dimeric protein that can form tetramers, hexamers and higher order oligomers. These forms have been suggested to play a role in RAGE activation. Oligomerization was found to require a low molecular weight trigger/cofactor and could not be detected for highly pure dimer, irrespective of handling.

2019年4月2日 · S100B protein is a cytosolic calcium-binding protein with a molecular weight of 21 kDa, which is present in various cells and concentrated mainly in the glial cells, which play a vital role in the maintenance of cellular homeostasis in the central nervous system.

2004年1月1日 · S100 proteins are 10–12 kDa in size and form homo- and heterodimers. The monomer is composed of two helix-loop-helix (EF-hand) motifs connected by a central hinge region (1) (3). The C-terminal EF-hand contains the canonical Ca 2+ -binding loop, common to all EF-hand proteins (e.g., troponin C or calmodulin).